摘要
对绞股蓝总皂甙（ＧＰＳ）的研究表明：急性毒性＞１０００Ｏｍｇ／ｋｇ，各项致突变试验结果均为阴性；在ＧＰＳ剂量为１０００、２５００，５００Ｏｍｇ／ｋｇ时由环磷酰胺所致小鼠骨髓细胞微核率分别为１１．９‰、８．５‰和１３．６‰均较环磷酰胺组的２９．９‰明显降低（Ｐ＜０．０５）。在５－５０μｇ／皿范围内，ＧＰＳ对ＴＡ９８、ＴＡ１００和ＴＡ１０２菌株经不同阳性物诱导后的菌落回变数有不同程度降低，对ＴＡ９８菌株在２－ＡＦ（Ｓ９＋）有良好的抗诱变作用，并呈剂量反应关系。结果提示，绞股蓝总皂甙在体内和体外均表现出明确的抗诱变作用。本文还对其抗诱变作用的可能机理进行了探讨。
The result showed that acute toxicity of GPS is over l0000mg/kg and has no
mutagenic potentialin the mutation assays. White animals were administrated GPS,the
micronucleus rate of PEC in mice bonemarrow induced by cyclophosphamide(CP)were
obviously inhibited.1000mg/kg 11.9‰,2500mg/kg 8.5‰,500Omg/kg 13.6‰ compared to CP 29.
9‰(P<0.05)。From 5-50mg/plate.GPS were also inhibited the re-version frequencies in strain
TA98,TA100 and TA102 by varied positive mutagens.GPS showed a good dose～respose
inhibition of revere mutation of strain TA98 induced by 2-AF(S9+).The results suggested
thatGPS have a possible antimugenesis in both vitro and vivo.The probable mechanism of
antimutagenesis of GPShas been suspected.
出处
《癌变．畸变．突变》
CAS
CSCD
1995年第3期160-163,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
皂甙
绞股蓝总皂甙
致突变性
抗诱变性
毒性
Gypenosides
Mutagenesis
Antimutagenesis
Micronucleus Test
Ames Tear.
