摘要
为了探讨绿脓杆菌多重耐药性的基因定位,1992年1月～1992年9月对我院烧伤病房分离的20株多重耐药性铜绿假单胞菌株进行了质粒消除。根据各种质粒消除前后的药物敏感试验,发现分离到的20株铜绿假单胞菌的多重耐药性有70%是由质粒所介导,有30%菌株仍耐药,分析原因为:①质粒未清除干净;②染色体编码的耐药性基因可能存在。我们在文章中对其在耐药性传播方面的作用进行了讨论。
20 strains of Pseudomonas aeruginosa were isolated from burn patients of Xijing Hospital in Xi'an. These 20 strains which showed resistance to multiple antibi- otics were selected to be studied regarding the location of multi-resistant gene. Accord- ing to the sensitivity tests before and after plasmid removal, we found that in 70% of the bacteria resistance to multiple antibiotics was mediated by the plasmid. In 30% the bacteria remained resistant to antibiotics after plasmids were removed. Two explana- tions were postulated. ①plasmids were not removed completely; ② resistance gene was encoded by the chromosomes.
