摘要
用羊抗兔肾毒血清在兔诱发肾毒血清性肾炎，然后用致死剂量的Ｙ射线进行全身照射，以去除血中白细胞或静脉大剂量注射肝素，抑制纤维蛋白生成，从而抑制了肾毒血清性肾炎新月体的生成，并避免了晚期尿毒症的发生。结果表明，在肾毒血清性肾炎时，新月体细胞主要来源于血中单核细胞。而纤维蛋白作为一种趋化因子，吸引单核细胞进入肾小球球囊腔中，积聚形成新月体，单核细胞在吞噬纤维素过程中转变为上皮样细胞。
ephrotoxic serum nephritis in rabbits resultedfrom the
administration of goat anti rabbit nephro-toxic serum. The rabbits with nephrotoxic
serumnephritis were irradiated generally with a lethal dose ofrray to deplete circulating
leukocytes or injected witha highdose heparin in vein to disturb fibrin formation.The results
showed that the glomerular crescent for-mation in nephrotoxic serum nephritis was
inhibitedand it was avoided that of the late stage of uremia. Theinvestigation indicated that ( 1 )
crescent cells, innephrotoxic serum nephritis, were mainly source ofcirculatingmonocytes; (2)
fibrin, as a chemotactic fac-tor, attracted the monocytes into Bowrnan, s space toform crescent
and (3) the monocyte, as phagocytosingfibrin ' transforms into epithelioid cell.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1995年第1期20-22,共3页
Chinese Journal of Nephrology
关键词
肾炎
肾毒血清
新月体
Nephrotoxic serum nephritisCrescent
