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大鼠新月体肾炎中的细胞增殖与凋亡 被引量:4

Cell proliferation and apoptosis in the rat crescentic glomerulonephritis
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摘要 目的探讨大鼠新月体肾炎时肾脏细胞凋亡与细胞增殖。方法分别用免疫组化(PCNA)和原位末端标记法检测增殖和凋亡的细胞。结果浸润肾脏的巨噬细胞及肾脏固有细胞,包括肾小管上皮细胞均发生凋亡,在细胞性、细胞-纤维素性新月体中及肾小管间质损害严重处凋亡明显,凋亡的肾小管上皮细胞数与肾小管病理损害程度高度相关。结论大鼠新月体肾炎时肾脏巨噬细胞和固有细胞均发生凋亡。 Objective To study the role of apoptosis in progressive renal injuryMethods Cell proliferation and apoptosis in a rat model of crescentic glomerulonephritis were examinedGroups of 5 rats were euthanized 1,7,14 and 21 days after the induction of the diseaseProliferating cells were identified by expression of PCNA using immunohistochemistry,while apoptotic cells were labeled with standard TUNEL methodResults The number of apoptotic cells continued to rise as the disease progressed,significantly correlated to the number of proliferating cells in both glomerular and tubulointerstitium respectively(070 and 084,both P<0001)Conclusion Apoptosis occurred in both infiltrating macrophages and intrinsic kidney cells and may play an important role in the progression of renal injury in the rat crescentic glomerulonephritis
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 1998年第3期147-150,共4页 Chinese Journal of Nephrology
基金 广东省科委自然科学基金
关键词 肾小球肾炎 巨噬细胞 细胞增殖 细胞凋亡 Apoptosis Proliferation Glomerulonephritis Macrophages
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