摘要
目的探讨婴幼儿血管瘤的病理演变过程。方法对52例婴幼儿血管瘤的标本进行HE染色,观察各阶段血管瘤的病理特点,利用图像分析系统分析血管瘤组织中细胞总数量、微血管总数量和总面积。结果出生后1～6个月,血管瘤中内皮细胞增殖快速,排列紧密,微血管数量迅速增加;7～12个月,血管瘤中内皮细胞迅速减少,微血管数量也减少但总面积明显扩大,并可见许多晚期凋亡细胞;1～3岁,大部分血管瘤组织呈微血管团样,微血管面积最大;4～5岁,微血管数量和总面积均迅速减少;5岁之后,大部分血管瘤消退完成,被纤维脂肪组织代替。结论内皮细胞数量、微血管数量和总面积的相对变化主导了婴幼儿血管瘤的病理演变过程。内皮细胞数量减少可能与凋亡有关。微血管的变化则可能与血管发生和血管塑形有关。
Purpose To observe the pathologic involution of infantile hemangioma and to analyze the pathogenesis of the tumor. Methods Fifty-two cases of infantile hemangioma were included in our study. HE stain was used to observe their pathologic structures and to analyze the number of cells,the number and area of the microvessels in the tumor with computer. Results During the first 1～6 months,the infantile hemangioma endothelial cells (ECs) proliferated very rapidly and they aggregated very tightly; The number of microvessels also increased quickly. Between the 7th to 12th month,the number of ECs and microvessels decreased. But the area of microvessels increased. There were many apoptotic cells in this period. Between the 2nd to 3rd year,most of infantile hemangiomas were composed of plenty of microvessels and the area of microvessels was the largest Between 4th to 5th year,the number and area of microvessels decreased quickly. After 5 years old,most of hemangiomas involuted completely and were replaced by the fat and fibrous tissues. Conclusions The changes of the number of ECs,the number and area of microvessels lead to the pathologic involution of infantile hemangioma. The decrease of the number of ECs may be attributed to the apoptosis of ECs and the change of microvessels may be related to the angiogenesis and vascular remodelling.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2005年第3期290-294,共5页
Chinese Journal of Clinical and Experimental Pathology
