摘要
目的探讨多囊卵巢综合征(PCOS)患者的血清抑制素、瘦素、血脂之间的相关性。方法检测了45例多囊卵巢综合征患者和20例月经正常的育龄期妇女作为对照组的血清瘦素、抑制素和血脂水平。结果多囊卵巢综合征患者血清中瘦素水平与甘油三脂、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B水平呈正相关(P均<0·01),与高密度脂蛋白胆固醇水平呈负相关(P<0·01),但同样结果未能在对照组中观测到。抑制素与瘦素表现为负相关关系(P<0·05)。与对照组相比,多囊卵巢综合征患者血清瘦素水平升高(P<0·01),抑制素水平无显著差异。结论瘦素水平与血脂在一定范围内相关,与PCOS可能不存在必然的联系;瘦素与抑制素存在负相关关系;多囊卵巢综合征患者组的抑制素水平虽然与正常对照组并无差别,但抑制素可能参与了PCOS性激素分泌失调的形成。
Objective To elucidate the correlation between leptin, inhibition and serum lipids in patients with PCOS. Methods Leptin, inhibition and serum lipids were assessed in 45 paients with polycystic ovary syndrome(PCOS) and 20 normal child-bearing period women. Results ①There were positive correlation(P<0.01) between serum triglyceride(TG), total cholesterol(TC), apolipoprotein(Apo) B, low-density lipoprotein-cholesterol(LDL) and leptin, and negative correlation(P<0.01) was found between high-density lipoprotein-cholesterol(HDL) and leptin, but the same results were not found in the 20 normal child-bearing period women. ②The serum leptin level were higher in PCOS than that in normal women(P<0.01). ③The serum inhibition levels were negatively correlated(P<0.01) with leptin. Conclusion Leptin levels were correlated with serum lipids and were negatively correlated(P<0.01) with inhibition.
出处
《中国实验诊断学》
2005年第3期374-376,共3页
Chinese Journal of Laboratory Diagnosis
关键词
多囊卵巢综合征
瘦素
抑制素
血脂
polycystic ovary syndrome
leptin
inhibition
serum lipids
