摘要
目的:建立复方醋酸地塞米松搽剂中樟脑和醋酸地塞米松的含量测定方法。方法:采用一阶导数光谱法于(305±1)nm波长处直接测定樟脑的含量;采用可见分光光度法于(485±1)nm波长处测定醋酸地塞米松的含量。结果:樟脑含量在1.62-3.22mg/mL浓度范围内,线性关系良好,相关系数r=0.999 4,平均回收率99.89%,RSD为0.34%。醋酸地塞米松含量在122.04-227.81μg/mL浓度范围内,线性关系良好, 相关系数r=0.999 7,平均回收率99.18%,RSD为1.32%。结论:本方法简便、快速、准确,可用于复方醋酸地塞米松搽剂的质量控制。
Objective: To establish a quantitative analysis method for camphor and dexamethason acetate in compound dexametha son acetate liniment. Methods: The camphor was determined directly at 305nm by first derivative spectrometry. The dexamethason acetate was determined at 485nm by seeable spectrometry. Results:The calibra-tion curve of camphor was linear in the range from 1. 62-3. 22mg/mL with r = 0. 999 4,the average recovery and relative standard deviation were 99. 89% and 0. 34% respectively. The calibration curve of dexamethason acetate was linear in the range from 122. 04-227. 81μg/mL with r = 0. 999 7 , the average recovery and RSD were 99. 18% and 1. 32% respectively. Conclusions: The method is simple, rapid and accurate. It can be used to control the quality of compound dexame-thason acetate liniment.
出处
《药学实践杂志》
CAS
2005年第3期167-169,共3页
Journal of Pharmaceutical Practice
关键词
一阶导数光谱法
可见分光光度法
复方醋酸地塞米松搽剂
樟脑
醋酸地塞米松
含量测定
first derivative spectrometry
seeable spectrometry
compound dexamethason acetate liniment
camphor
dexamethason acetate
determination of content
