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钾离子通道与前列腺疾病 被引量：2

Potassium Ion Channels and Prostatic Diseases
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摘要 钾离子通道(potassiumionchannels)是镶嵌在细胞膜脂质中的蛋白复合体,在正常前列腺上皮细胞中强表达,在前列腺癌上皮细胞中有不同程度的低表达,而在慢性前列腺炎上皮细胞中的表达还不清楚。作用于钾离子通道的药物可为前列腺疾病的治疗提供新的方向和思路。 Potassium ion channels are a complex of protein molded in the cell membrane lipids. Its expression is strong in normal prostatic epithelia and weak in different degrees in prostatic cancer epithelia, but not clearly known in chronic prostatitis epithelia. Drugs affecting potassium ion channels could provide a new direction and some new ideas for the treatment of prostatic diseases.
作者 郭清奎 梁朝朝
机构地区 安徽医科大学第一附属医院泌尿外科
出处 《中华男科学杂志》 CAS CSCD 2005年第6期458-461,共4页 National Journal of Andrology
关键词 钾离子通道 前列腺疾病 potassium ion channels prostatic disease
分类号 R697.3 [医药卫生—泌尿科学]
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参考文献27

  • 1Laniado ME, Abel PD, Lalani EN. Ion channels [J]. BMJ,1997, 315(7117): 1171-1172. 被引量：1
  • 2Gutman GA, Chandy KG, Adelman JP, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels [J]. Pharmacol Rev, 2003, 55(4) :583-586. 被引量：1
  • 3Ouadid-Ahidouch H, Van Coppenolle F, Le Bourhis X, et al.Potassium channels in rat prostate epithelial cells [J]. FEBS Lett, 1999, 459(1) :15-21. 被引量：1
  • 4陈小章等主编..外分泌生理学 基础与临床[M].北京:科学出版社,2003:591.
  • 5Rybalchenko V, Prevarskaya N, Van Coppenolle F, et al. Verapamil inhibits proliferation of LNCaP human prostate cancer cells influencing K+ channel gating [J]. Mol Pharmacol, 2001, 59(6):1376-1387. 被引量：1
  • 6潘雅萍,徐向华,王晓良.双孔钾通道的结构、功能及药理学研究[J].中国药理学通报,2002,18(4):369-373. 被引量：3
  • 7贾宏钧等主编..离子通道与心脑血管疾病 基础与临床[M].北京:人民卫生出版社,2001:693.
  • 8Laniado ME, Fraser SP, Djamgoz MB. Voltage-gated K^ + channel activity in human prostate cancer cell lines of markedly different metastatic potential: distinguishing characteristics PC-3 and LNCaP cells [J]. Prostate, 2001,46(4) :262-274. 被引量：1
  • 9Griffith TM. Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis[J] ? Br J Pharm, 2004, 141(6) :881-903. 被引量：1
  • 10Kim JH, Shin SY, Yun SS, et al. Voltage-dependent ion channel currents in neuroendocrine cells dissociated from the ventral prostate of rat [J]. Pflugers Arch, 2003, 446 (1):88-99. 被引量：1

二级参考文献47

  • 1夏同礼,孔祥田,宓培,王静华,苏晋伟.我国成人前列腺非特异性炎[J].中华泌尿外科杂志,1995,16(12):711-712. 被引量：82
  • 2[1]Coetzee WA,Amarillo Y,Chiu J et al. Molecular diversity of K+ channels. Ann NY Acad Sci,1999;868:233～85 被引量：1
  • 3[2]Ketchum KA,Joiner WJ,Sellers AJ et al. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature,1995;376: 690～5 被引量：1
  • 4[3]Lesage F,Guillemare E,Fink M et al. TWIK-1,a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J,1996;15:1004～11 被引量：1
  • 5[4]Patel AJ,Lazdunski M,Honore E. Lipid and mechano-gated 2P domain K+ channels. Curr Opin Cell Biol,2001;13:422～8 被引量：1
  • 6[5]Wang ZW,Kunkel MT,Wei A et al. Genomic organization of nematode 4TM K+ channels. Ann NY Acad Sci,1999;868:286～303 被引量：1
  • 7[6]Lesage F,Reyes R,Fink M et al. Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J,1996;15:6400～7 被引量：1
  • 8[7]Chavez RA,Gray AT,Zhao BB et al. TWIK-2,a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem, 1999;274: 7887～92 被引量：1
  • 9[8]Lesage F,Guillemare E,Fink M et al. TWIK-1,a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J, 1996;15:1004～11 被引量：1
  • 10[9]Lesage F,Lauritzen I,Duprat F et al. The structure,function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett,1997;402:28～32 被引量：1

共引文献105

同被引文献21

  • 1陈卫国,严春寅,浦金贤,侯建全,温端改,郭震华.转化生长因子调控表皮生长因子受体在雄激素非依赖型前列腺癌细胞中表达的意义[J].中华男科学杂志,2004,10(8):595-597. 被引量：4
  • 2姚小鹏,李强,董宇超,黄海东,张伟.钾通道与肺动脉平滑肌细胞增殖和凋亡关系中钙通道所起作用的研究[J].第二军医大学学报,2005,26(6):632-635. 被引量：4
  • 3Hayward SW,Rosen MA,Cunha GR.Stromal-epithelial interactions in the normal and neoplastic prostate.Br J Urol 1997; 79(Suppl 2): 18-26. 被引量：1
  • 4Rybalchenko V, Prevarskaya N, Van Coppenolle F, et al. Verapamil inhibts proliferation of LNCaP human prostate cancer cells influencing K^+ channel gating J. Mol Pharmacol 2001 ; 59(6): 1376-1387. 被引量：1
  • 5Krick S,Paloshyn O,McDaniel SS,et al.Augmented K^+ currents and mitochondrial membrance depolarization in pulmonary artery myocyte apoptosis J. Am J Physiol Lung cell Mol Physiol 2001; 281(4): L887-894. 被引量：1
  • 6Yu SP, Ych CH, Gouron F, et al. Role of the outward delayed rectifier K^+ current in co-amide-induced caspase activation and apoptosis incultured cortical ncurons J. J Neurochem 1999; 73(3): 933-941. 被引量：1
  • 7Nagy E Panyi G, Jenei A, et al. Ion-channel activities regulate transmembrane signaling in thymocytc apoptosis and T-cell activation J. Immunol Lett 1995;44(2-3): 91-95. 被引量：1
  • 8Beauvais F, Michel L, Dubertret L. Human cosinophils in culture undergo a striking and rapid shrinkage during apoptosis:role of K+Channels. J. J Leukoc Biol 1995;57(6): 851-855. 被引量：1
  • 9Yu SP. Regulation and critical role of potassium homeostasis in apoptosis J. Prog Neurobiol 2003; 70(4): 363-386. 被引量：1
  • 10Wade GR, Laurier LG, Preiksaitis H G, et al. Delayed rectifier and Ca^2+-dependent K^+current in human esophagus:roles in regulating muscle contraction J. Am J Physiol 1999; 277:G885-895. 被引量：1

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中华男科学杂志
2005年 第6期

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