摘要
目的:研究细胞表面粘附分子CD44在肾细胞癌外周血淋巴细胞中表达及临床意义。方法:根治术的肾细胞癌59例,男39例,女20例,年龄20～67岁。CD44表达应用流式细胞免疫学方法检测,并与正常对照(n=30)进行比较。结果:肾细胞癌外周血淋巴细胞中CD44表达均明显高于正常对照(P<0.01),手术后2周和12个月表达降低,但仍高于对照(P<0.05)。T3+T4期CD44表达明显高于T1+T2期(P<005),肾癌有转移患者CD44表达均高于无转移者(P<0.01),肾癌不同组织类型的CD44表达无显著性差异(P>005)。结论:肾癌患者CD44表达水平明显高于正常对照,且手术后可以明显下降,其表达水平与肾癌的进展情况及有无转移、预后有一定关系。
Objective::To study the expression of peripheral blood CD44 in primary renal cell carcinoma (RCC). Methods: Data of fifty-nine patients (male 39, female 20, age ranging from 20 to 67) with renal cell carcinoma underwent nephrectomy were reviewed, and 30 normal donors served as controls. The expression of peripheral blood CD44 was detected by flow-cytometry. Results:The peripheral blood lymphocyte CD44 contents in patients with RCC were significantly higher than those in normal controls (-P-<0.01), and CD44 was lower (-P-<0.05) after operation in 2 weeks and 12 months. Distinct statistic difference was found between CD44 in stage T3-T4 and T1-T2 (-P-<0.05); RCC with metastasis or distance metastasis showed higher expression of CD44 than RCC without metastasis or distance metastasis. No difference in CD44 contents was observed in different histopathological types of RCC (-P->0.05). Conclusion: The peripheral blood lymphocyte CD44 contents in RCC are significantly higher, and CD44 is lower after operation. The CD44 expression in RCC might be an important means to differentiate benign from malignant renal tumor, and to detect invasion or metastasis and estimate the prognosis of RCC.
出处
《西北国防医学杂志》
CAS
2005年第3期182-184,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
肾肿瘤
外周血
CD44
流式细胞免疫学
Kidney neoplasm
Peripheral blood
CD44
Flow-cytometry cellular immunology
