摘要
目的 探讨大鼠感染斯氏狸殖吸虫后肝功能的动态变化。方法 将大鼠随机分成对照组和实验组,用斯氏狸殖吸虫囊蚴经腹腔注射感染实验组大鼠,用全自动生化分析仪于感染后不同时间分别检测2组大鼠血清总蛋白、白蛋白、球蛋白、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)。并进行统计分析。结果 感染后4、6、8周实验组大鼠血清白蛋白含量明显下降(P <0 .0 5 ,P <0 .0 1,P <0 .0 1) ,而血清球蛋白含量明显升高(P <0 .0 1,P <0 .0 1,P <0 .0 5 ) ;总蛋白含量在感染后变化不明显(P >0 .0 5 ) ;感染后6、8周,ALT(P <0 .0 5 ,P <0 .0 1)与AST(P <0 .0 5 ,P <0 .0 5 )活性均升高;肝功能各指标在感染后的前2周变化不明显(P >0 .0 5 )。结论 大白鼠感染斯氏狸殖吸虫后,肝功能主要表现为白蛋白减少和球蛋白增加。因此,白蛋白减少和球蛋白增加可作为斯氏狸殖吸虫病肝脏损害的一个诊断指标。
To observe the dynamic changes in liver of rats infected with Parumogonimus skrjabini, 19 rats were randomly divided into two groups, in which 11 were in experimental group and 8 in control group, and the former group of rats were each injected abdominally with metacercariae of P.skrjabini. The serum levels of total proteins, albumin, globulin, alanine aminotransferase (ALT)and aspartate aminotransferase (AST) of rats after 1, 2, 4 and 8 weeks of infection were determined by automatic biochemical analyzer in these two groups of rats. Data were analyzed with SPSS 10.0 statistic software. It was found that the serum levels of albumin in the experimental group were significantly lower than those in the control group after 4, 6 and 8 weeks of infection, but the serum levels of globulin, ALT and AST in the experimental group were markedly increased after 6 and 8 weeks of infection. There had no obvious changes in serum total globulin during the whole course of infection, and these changes were not significant in the first 2 weeks after infection . It indicates that the infection by P.skrjabini can induce damages of the liver functions in the infected rats, and thus the reduction of albumin and elevation of globulin appear to serve as a diagnostic indices for the P.skrjabini infection.
出处
《中国人兽共患病杂志》
CSCD
北大核心
2005年第4期326-328,共3页
Chinese Journal of Zoonoses
基金
云南省教育厅科研基金资助项目 (0 4J2 92C)
关键词
斯氏狸殖吸虫
肝功能
Pagumogonimus skrjabini
liver function
