摘要
痛风是一种以血尿酸增高为特征的代谢性疾病 ,近年来随着我国人民生活水平的提高 ,高尿酸血症和痛风的发病率逐年上升 ,因而研制防治痛风和高尿酸血症的药物已成为当前医药界研究的热点 ,但实验动物模型的困难严重地影响着研究工作的开展。本文对目前常见的痛风和高尿酸血症实验动物模型进行了较系统的简介 ,并根据笔者的研究经验进行了简要评价 ,供致力于该方面研究的学者参考。
Gout is a metabolic disease characterized by a significant hyperuric emia. In recent years the incidence of gout is rapidly increasing along with the development of China. Therefore, the prevention and treatment of gout aroused g reat interests among medical researchers. However, there is still a lack of suit able and reliable experimental animal models of gout and hyperuricemia. This art icle is a brief overview of recent advances in how to establish animal models of gout and hyperuricemia, and an introduction of own work and experiences of the authors, which could be beneficial in future research.
出处
《中国实验动物学报》
CAS
CSCD
2005年第1期55-58,共4页
Acta Laboratorium Animalis Scientia Sinica
