摘要
将新西兰兔分为三组,A组:整个孕期被动吸烟:B组:孕后半期被动吸烟;C组:对照组,结果A、B两组母兔体重增加(分别为0.65kg及0.85kg)较对照组(1.18kg)少;胎仔的体重、肝、脑重量及胎盘重量均较对照组轻,其中以体重及肝脏重量相差更明显(P<0.001):吸烟两组的子宫胎盘血流量与对照组比较明显减少(P<0.001):吸烟两组IUGR发生率(分别为48.33%及20.37%)较对照组(3.45%)明显增加(分别为P<0.0001、P<0.05).整个孕期被动吸烟的孕兔可产生混合型IUGR动物模型,孕后半期被动吸烟则产生不对称型IUGR动物模型。
Pregnant New Zealand rabbits were exposed to cigarette smoking in 2 groups: A. Daily exposure to smoking during the entire course of pregnance. B. Daily exposure in the late half period of pregnancy. Group C was used as control. The weight gain in pregnancey, fetal devdopment and uteroplacental blood flow were investigated. Results showed that the weight gain in the experimental groups was much less than that in the control group. The body weight of the new born offsprings adn thje weitht of placenta, liver and brain were also significantly lighter (P<0.05). Cigarette smoking also reduced the uteroplacental blood flow significantly. The rote of IUGR was much higher (48.33% and 20.37%) in groups A and B than that in group C(3.45%)(P<0.05). A mixed type fo IUGR animal model could be induced in group A and an asymetrical type of IUGR modal in group B rabbits.
出处
《上海第二医科大学学报》
CSCD
1993年第4期314-317,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
吸烟
宫内生长迟缓
胎儿
smoking intrauterine growth retardation uteroplacental blood flow
