摘要
铀促排药物研究ＶⅢ：邻苯二酚类鳌合剂的新法合成覃兆海，谢毓元（北京农业大学应用化学系１０００９４，中国科学院上海药物研究所上海２０００３１）近几年的研究发现，含有邻苯二酚残基的螯合剂，如２，３－二羟基－４－（或－５－）烷氧羰基苄基胺羧酰胺（Ｉ）等对小...
In further study on
the synthesis of chelating agents with catechol residue,twoconvenient
procedures-ethyl chloroformate method and
dicyclohexylcarbodiimide(DCC)method-weredeveloped.The latter was used
successfully to synthesize chelating agents with several catechol
units.These compounds are more effective than compounds with only one
catechol unit to detoxicate micewhich were under acute UO2(NO3)2
intoxication(LD95～100).
出处
《药学学报》
CAS
CSCD
北大核心
1994年第12期929-933,共5页
Acta Pharmaceutica Sinica
关键词
铀促排药
邻苯二本酚类
螯合剂
合成
铀中毒
Uranium mobilization
agents
N-carboxymethyl-N-(substituted
carhamoylmethl)-2,3-dihydroxy-4-carbomethoxybenzylamine
N,N′,N″,…
-poly-(N-carboxymethyl-N-(2,3-dihy-droxy-4-carbomethoxy
benzyl)-glycyl)-polyethylene polyamines
