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急性心肌梗死患者再灌注治疗对血浆脑钠素水平和左心室重塑的影响 被引量:4

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摘要 目的探讨急性心肌梗死患者接受早期再灌注治疗后血浆脑钠素水平和左心室重塑的变化.方法急性心肌梗死患者56例,胸痛发作12 h内接受并成功再灌注治疗者(38例)为试验组,未接受再灌注或再灌注治疗失败者(18例)为对照组.ELISA法测定入院即刻、24 h、48 h、7 d、14 d、28 d时血浆脑钠素水平;入院后3~5 d、28 d超声心动图测量左心室舒张末期容积指数、左心室收缩末期容积指数、左心室射血分数,并计算他们的变化量.结果①急性心肌梗死患者血浆脑钠素水平较正常人明显升高;试验组血浆脑钠素水平呈单峰曲线,对照组呈双峰曲线;再灌注可明显降低急性心肌梗死患者脑钠素水平,其第7天时浓度升高不明显,未形成第2个高峰.②再灌注治疗能减少左心室容积增加并提高左心室射血分数.③血浆脑钠素水平与急性心肌梗死后左心室重塑的程度相关,尤其以急性心肌梗死后第7天时脑钠素浓度最有意义.结论早期再灌注治疗可明显降低急性心肌梗死患者血浆脑钠素水平并减轻左心室重塑,血浆脑钠素水平与急性心肌梗死后左心室重塑的程度相关.
出处 《中国综合临床》 北大核心 2005年第4期311-313,共3页 Clinical Medicine of China
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