摘要
目的观察硝普钠、多巴胺与利尿剂合用治疗低血压合并慢性充血性心衰的疗效、安全性及其对患者血浆氨基末端脑钠肽(Nt-proBNP))浓度的影响。方法将105例心衰患者随机分为治疗组和对照组,对照组给利尿剂与氨茶碱治疗;治疗组在对照组基础上加用硝普钠与多巴胺,观察10d,并对两组的心功能改善、症状改善及心脏彩超进行对比,并采用ELISA法对两组患者治疗前后血浆Nt-proBNP进行测定。结果治疗组总有效率94.5%,显效率60.2%,治疗后左室射血分数(LVEF)显著高于对照组(P<0.05);治疗组治疗后血浆Nt-proBNP水平显著低于对照组(P<0.05)。结论硝普钠与多巴胺联用在治疗低血压合并慢性充血性心衰中有重要意义,血浆Nt-proBNP水平在心衰治疗疗效评价中有较高敏感性。
Objective To detect effect and safety of combination of sodium nitroprusside, dopamine in treatment of chronic heart failure（ CHF）, and the effect on level of plasma Nt - proBNP. Methods 105 patients with heart failure were divided into treatment group and control group randomly. The control group was treated with diuretic and aminophylline. And treatment group was treated with sodium nitroprusside, dopaine additionally. The treatment last 10days. Comparison was done between two groups, as the evaluation of improvement of heart function, improvement of signs of heart failure, the change of left ventricular ejection fraction （LVEF） and left ventricular end - diastolic diameter （LVDd） by uhrasonography of heart as evaluation index, and the level of plasma Nt - proBNP was measured before and after treatment in each group. Results The total effective rate （ 94. 5 % ）, total responsive rate（ 60. 2% ）, LVEF in treatment group were significantly higher than those in control group after treatment（ P 〈 0. 05 ）. And the plasma Nt -proBNP level was significantly lower than that in control group （ P 〈 0. 05）. Conclusion Effects of combination of sodium nitroprusside, dopaine in treatment of low blood pressure with CHF were significant. Plasma Nt -proBNP level has considerably high sensibility in the evaluation of treatment effect of heart failure.
出处
《医药论坛杂志》
2007年第10期3-4,共2页
Journal of Medical Forum
