摘要
孕酮拮抗剂米非司酮（ＲＵ４８６）在离体下对人子宫内膜间质细胞分泌组织型纤溶酶元激活因子（ｔＰＡ）及腺体细胞分泌尿激酶型纤溶酶元激活因子（ｕＰＡ）均有刺激作用，并抑制两种细胞分泌纤溶酶元激活因子的抑制因子（ＰＡＩ－１），其作用与孕酮相反。内美通（Ｒ２３２３）抑制ｔＰＡ和ｕＰＡ而刺激ＰＡＩ－１在二种细胞中的分泌，其作用与孕酮一致。提示ＲＵ４８６催经止孕、Ｒ２３２３抑制异位子宫内膜作用有可能是通过影响两种ＰＡ和ＰＡＩ—１的平衡介导的。
In cultured human endometrial cells we have demonstrated that RU486 stimulates boht tPA (produced by stroma cells) and uPA (by glandular cells), but inhibits PAI-1 (by both cell types) secretion in a dose-dependent manner, in contrast, progesterone and R2323 increase PAI 1, decrease both PA production in the cultured cells, suggesting that RU486 counteracts the biological effect of progesterone at the receptor level. It is therefore suggested that the contraceptive and early contragstational action of RU486 may be mediated by promoting fibrinolysis of the endometrum via increase in PA production. While R2323 exerts therapeutic action on endometriosisby its inhibition of PA in the tissue.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1994年第5期328-331,共4页
Reproduction and Contraception
关键词
子宫内膜
UPA
纤蛋白溶酶
米非司酮
内美通
Endometrium, Plasminogen activator, Plasminogen activator inhibitor,RU_(486), R_(2323)
