摘要
使用补肾方剂（补肾健骨胶囊）对切除卵巢的雌性成年大鼠进行了不同剂量的药物治疗，并与正常对照组、模型组和尼尔雌醇治疗组的大鼠进行了对比。统计学结果显示，补肾健骨胶囊治疗可有效改善卵巢切除大鼠骨质疏松症，各项骨检测指标明显好于模型组，差异有显著性和非常显著性（Ｐ＜０．０５～０．００１）。补肾健骨胶囊治疗后大鼠骨载荷、骨桡度、骨强度等生物力学指标明显好于模型组（Ｐ＜０．０５～０．００１）。说明补肾健骨胶囊治疗可明显的改善骨质疏松大鼠的骨质丢失状态，提高骨骼抵抗外力冲击的能力，有效的防治骨质疏松症，避免骨折的发生。
Ovariectomized female adult rats were treated with kidney tonifying herbs(Bu Shen Jian Gu capsules, 补肾健骨胶囊 BSJG)in different dosages, and compared with groups of normal control,model,and nilestriol-treated rats. Statistical results showed that treatment with BSJG capsules improved the osteoporosis of ovariectommized rats;the biochemical parameters related to bone metabolism were significantly better than those in the model group (P<0. 05-0. 001). After treatment with BSJG capsules,the biomechanic parameters such as bone loading,defletion and strength were also significantly better than those in the model group ( P<0. 05-0. 001). The results indicate that treatment with BSJG capsules can reduce the bone loss of osteoporotic rats,improve the biomechanic properties of the bones,prevent osteoporosis and resist fracture effectively.
出处
《中国骨质疏松杂志》
CAS
CSCD
1996年第1期25-27,31,共4页
Chinese Journal of Osteoporosis
基金
国家中医药管理局八.五重点课题
