摘要
龙晶一号(L01)是从飞龙掌血中分离出的有效成分。L01 45～405μmol/L可拮抗KCl和NE所致大鼠主动脉环收缩,其IC_(50)分别为206.93和94.18μmol/L。L01可使CaCl_2的量效反应曲线平行右移,其对PDC的阻滞作用与Ver相似。L01 80μmol/L抑制NE所致细胞内Ca^(2+)释放和外Ca^(2+)内流,对前者作用较显著,与Ver有别。提示L01可能为一种新的钙拮抗剂。
Long Jing 1 (L01) is the effective component extracted from asiatic todd-alia. In the experiments on rat thoracic aortic rings, L01 45-405 μmol/L inhibited thecontraction initiated by high K^+ or NE, the IC_(50) value was 206.93 and 94.18 μmol/Lrespectively. L01 shifted the dose-response curve of KCl or NE to the right, and reducedthe maximal response, also shifted that of CaCl_2 to the right parallelly. The effects ofL01 were similar to that of Ver (verapamil) in the blockage on PDC. Morever L01 80 μmol/Linhibited the release of intracellular Ca^(2+) and extracellular Ca^(2+) influx initiated by NE,the former effect was more significant than the latter (this was different from Ver). Theseresults suggested that L01 was probably a new calcium antagonist different from Ver.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第2期129-132,共4页
Chinese Journal of Pathophysiology
基金
国务院侨办重点学科科研基金
暨南大学青年科学基金
关键词
飞龙掌血
主动脉
胸
钙拮抗剂
Asiatic toddalia
Aorta,thoracic
Verapamil
Calcium channel blockers
