摘要
目的观察当归、红芪及其合剂超滤膜提取物对急性心肌缺血大鼠平均动脉压(MAP)、肌酸激酶同工酶(CK-MB)的影响。方法以冠状动脉前降支结扎法32只大鼠制造急性心肌缺血模型;造模成功后,将随机分为1 d、3 d、7 d1、4 d组,每组8只;采用拉丁方设计实验方法对动物进行用药;应用Power Lab多道生理记录仪测定大鼠MAP,用全自动生化仪测定血清CK-MB含量。结果MAP和血清CK-MB含量在不同时间组大鼠之间和不同药物组大鼠之间均有显著性差异(P<0.05和P<0.01)。结论当归、红芪及其合剂超滤膜提取物有促进急性心肌缺血大鼠MAP回升和降低血清CK-MB活性的作用,且与用药时间密切相关。
Objective It is to observe the effect of ultra- filtration extract from Angelica sinensis （AS）, Hedysarum polybotrys （HP） and their mixture on mean artery pressure （MAP） and CK- MB in rats with acute myocardial ischemia, Methods Myocardial ischemia models of 32 rats were made by anterior descending coronary ligation and were randomly divided into 1 d group, 3 d group, 7 d group, 14 d group. Each group including 8 animals was given drugs by design experimental method with latin square. MAP were detected by multi-path physiological recording instrument named as Power Lab. The content of CK - MB was measured by automated biochemical instrument. Results There were significant differences in MAP and CK MB in different time groups and in different drug groups （P 〈 0.05 or 0.01）. Conclusion The ultra - filtration extract from AS, HP and their mixture has a function on increasing MAP and decreasing the activity of CK - MB, which is related to time length of treatment.
出处
《现代中西医结合杂志》
CAS
2006年第10期1297-1299,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
当归
红芪
超滤膜
急性心肌缺血
平均动脉压
肌酸激酶同工酶
Angelica sinensis
Hedysarum polybotrys
ulter-filter
acute myocardial ischemia
mean artery pressure
CK- MB
