摘要
To study the antifungal effect of chalcone derivatives. Methods Sixteenchalcone derivatives were synthesized and confirmed by ~1H NMR and IR spectra, and tested forantifungal activity against four common pathogenic fungi. Their structure-activity relationship isdiscussed. Results Among 16 title compounds, there were 5 new compounds, which have not beenreported before. The preliminary antifungal test showed that all title compounds exhibitedantifungal activities to a certain extent. The activity of compound 8 against Trichophyton rubrumhad a potency equal to that of fluconazole, with a MIC of 4 μg·mL^(-1) . Conclusion Sixteenchalcones were prepared and their antifungal activities against four common pathogenic fungi invitro were examined. Some of them exhibited antifungal activities to a certain extent.
目的 合成查耳酮类化合物并测定其抗真菌活性。方法 利用Claisen Schmidt反应合成查耳酮 ,并针对四种真菌(白色念珠菌、新生隐球菌、烟曲霉菌、红色毛癣菌 )做了体外抗真菌活性筛选。结果 显示所合成化合物大多具有体外抗真菌活性 ,尤其化合物 8,其针对浅表菌的抗真菌活性与氟康唑相当。本文还对部分查耳酮的合成做了一些探索。结论 所合成的查耳酮均有不同程度的抗真菌活性 ,其化学结构差异与抗菌活性相关。
