摘要
目的观察载脂蛋白E(ApoE)的遗传多态性与老年人血脂的关系。方法808例受试者,其中脑卒中430例、冠心病167例及对照组211例。采用聚合酶链式反应限制性片段多态性方法检测ApoE基因多态性。结果ApoE4表型携带者的TC、LDLC和ApoB水平显著高于ApoE2表型携带者(P<005),ApoE3/3表型携带者的LDLC水平也高于ApoE2表型携带者(P<005),而ApoE2表型携带者的HDLC水平显著高于ApoE4(P<005),这种作用在男女两性中相似。结论ApoE基因多态性影响老年人群血脂水平,无性别差异。
Objective To investigate the relationship between apolipoprotein E (ApoE) gene polymorphism and blood lipid in the elderly.Methods 808 subjects were studied. Among them, there were 430 patients with stroke, 167 patients with coronary heart disease and 211 control subjects. Polymerase chain reaction-restricted fragments length polymorphism was used to determine ApoE gene polymorphism. Results The subjects with ApoE4 phenotype had significantly higher levels of TC, LDL-C and ApoB than those with ApoE2 phenotype (P<0.05); the ApoE3/3 phenotype carriers had significantly higher LDL-C levels than the ApoE2 phenotype carriers (P<~0.05 ); the ApoE2 phenotype carriers had significantly higher HDL-C levels than the ApoE4 phenotype carriers (P<0.05). The effect appeared no difference in male and female. Conclusions ApoE gene polymorphism affect level of blood lipid with no difference in male and female.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2005年第1期10-12,共3页
Chinese Journal of Gerontology
关键词
载脂蛋白E
基因多态性
血脂
Apolipoprotein E (ApoE)
Gene polymorphism
Serum lipid level
