摘要
目的 探讨血浆vWF、GMP - 14 0在布 -加综合征 (B CS)中变化和临床意义及病理生理意义。方法 采用双抗体夹心固相酶免疫试验方法 (ELISA)分别测定 6 0例B -CS与 30例对照者血浆vWF、GMP - 14 0水平。结果 发现B -CS血浆中 ,vWF、GMP - 14 0水平比对照组显著增高 (P <0 .0 1) ,同时发现B -CS血浆vWF、GMP - 14 0水平与血小板计数之间的关系不相关 (r分别为 - 0 16 4及 - 0 0 36 9,P >0 .0 5 )。结论 B -CS患者血浆vWF、GMP - 14 0的升高可能是导致B -CS患者高凝状态的一种常见的重要的因素。
Objective To explore the clinical and pathophysiologyic significance of change of plasma vWF、GMP-140 in patients with B-CS. Methods vWF,GMP-140 were detected in 60 patients with B-CS and 30 controls using enzyme-linked immunosirbent assay(ELISA).Results The level of vWF GMP-140 were significantly increased in B-CS comparison with controls(P<0.01),Moreover,there was no significant correlation between the vWF or GMP-140 and the platelet count in B-CS(r=-0.164 and -0.0369 ,P>0.05) .Conclusion High quantity of vWF GMP-140 in patients with B-CS suggest that the hypercoagulable state of B-CS may be mainly caused by the increase of vWF、 GMP-140.
出处
《医药论坛杂志》
2004年第17期17-18,20,共3页
Journal of Medical Forum
