摘要
目的 探讨热重 (TG)、差热 (DTA)分析技术在药物配伍禁忌研究中的应用意义。方法 试验选用了维生素C片与氨茶碱片 ,葡萄糖酸锌片剂与头孢氨苄胶囊四种药品 ,并粉碎成 - 2 0 0目的粉末后 ,先将每种药物进行TG、DTA扫描 ,然后将葡萄糖酸锌和头孢氨苄胶囊各占 5 0 %进行混合 ,维生素C和氨茶碱各占 5 0 %进行混合 ,并分别对这两种混合物进行热重、差热分析。结果 实验分析表明葡萄糖酸锌和头孢氨苄胶囊混合及维生素生C和氨茶碱混合都发生相互作用 ,特别是从它们的DTA曲线看 ,两组药物配伍后的相互作用非常明显。结论 热重、差热分析法的研究结果与通常的考察结果相一致 ,而且具有快速、简便的特点 ,值得推广。
Objective: To study the application of thermogravimetry(TG) and differential thermal analysis(DTA) in incompatibility of drugs. Methods: Four kinds of the drug, vtamin C tablets, aminophylline tablets, zincous gluconate tblets and cefalexin capsules were used in the experiment. The sizes of drugs were less than 200 mesh by grinding. Each drugs, the blend of zincous gluconate tblets(50%) with cefalexin capsules(50%) and the blend of vtamin C tablets(50%) with aminophylline tablets(50%) were analysed by TG and DTA. Results: The results showed that the blends reacted to each other which could be distinctly seen from DTA curves. Conclusion: The study shows that the results conform to accord with the ones concluded by conventional methods, and it is more rapid, simple and convenient.
出处
《泰山医学院学报》
CAS
2003年第4期381-383,共3页
Journal of Taishan Medical College
关键词
配伍禁忌
热重分析
差热分析
incompatibility
thermogravimetry
differential thermal analysis
