摘要
转运体是位于细胞膜上的功能性膜蛋白。目前研究证明转运体在药物的吸收、分布以及排泄过程中发挥着重要的作用,其中以肠道、肝脏以及肾脏转运体的作用最为明显。疾病状态下转运体的表达和功能会发生改变,影响药物在体内的处置过程,使药物的药代动力学发生明显改变而对疾病的药物治疗产生影响。本文综述了常见肠道疾病、肝脏疾病、肾脏疾病以及糖尿病状态下相关转运体的变化及其对临床药物治疗的影响。
Drug transporters are functional membrane proteins located in various tissues, which play vital roles in absorption, distribution and excretion of drugs, especially those located in intestine, liver and kidney. The expression and function of transporters will alter in diseases state, which affects the therapeutic effects of drugs by altering their pharmacokinetics. In this review, we focus on the alterations in related transporters and the effect on the drug therapy in common intestinal diseases, liver diseases, kidney diseases and diabetes mellitus.
出处
《药学学报》
CAS
CSCD
北大核心
2015年第2期127-132,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81473280
81273580)
关键词
转运体
肠道疾病
肝脏疾病
肾脏疾病
糖尿病
transporter
intestinal disease
liver disease
kidney disease
diabetes mellitus
