摘要
关于药物在机体内的跨膜转运机制,以往的研究多侧重于药物理化性质。近年,发现体内存在多种转运蛋白(转运体)系统,对药物体内跨膜转运,有重要意义,有时甚至起决定性作用,因此,药物转运体对药物的体内过程,即药物的吸收、分布、代谢和排泄及药物之间的相互作用有重要影响,并可影响或决定药物的动力学过程。
Concerning the transportation of a drug crossing cellular barriers, previous studies have placed emphasizes on chemical characters of the drug, particularly on its lipophilic property. Recently, a lot of trans-membrane proteins （transporters） have been found and they have shown important role in the transport of the drug crossing cellular membrane and may, therefore, affect pharmacokinetic process of drug in the body.
出处
《安徽医药》
CAS
2005年第10期721-723,共3页
Anhui Medical and Pharmaceutical Journal
