摘要
目的研究利巴韦林在大鼠各肠段的吸收动力学特征。方法应用大鼠在体灌流肠吸收实验考察其吸收动力学 ;采用HPLC法测定利巴韦林在大鼠体内肠吸收回流液中的药物浓度 ;采用UV法测定回流液中酚红浓度的变化。结果利巴韦林在小肠中上部吸收较好 ,吸收速率按十二指肠、空肠、回肠、结肠依次下降 ,吸收速率常数依次为 0 0 970 0、0 0 15 0 0、0 0 0 110、0 0 0 0 0 5h-1;回流液中吸收药物的量与利巴韦林的浓度成正比。结论利巴韦林在肠道的吸收呈一级吸收动力学特征 ,吸收机制为被动吸收 ;主要吸收部位为十二指肠和小肠上部 ,结肠几乎无吸收 ;提示该药适合制成日服
Objective To determine the absorption characters of ribavirin from various intestinal segments. Methods The absorption kinetics was investigated using the in situ perfusion method in rats.The concentration change of ribavirin in intestinal liquid of rats was measured by HPLC.Results Ribavirin has the better absorption in the upper parts of the small intestines.The absorption rate constants were (0.097 00),(0.015 00),(0.001 10),(0.000 05 h^(-1)) respectively at duodenum,jejunum,ileum and colon.Conclusions The absorption of ribavirin complies with the passive transport mechanism and first order kinetics.The main intestinal segments of the drug absorption is duodenum and jejunum,in colon the drug absorption amount is little.
出处
《沈阳药科大学学报》
CAS
CSCD
2004年第6期401-404,共4页
Journal of Shenyang Pharmaceutical University
关键词
利巴韦林
在体肠吸收
被动扩散
ribavirin
in situ intestinal absorption
passive diffusion
