摘要
目的研究金蒿抗流感滴丸一枝蒿、贯叶金丝桃中一枝蒿酮酸和金丝桃苷在大鼠肠吸收特性。方法采用大鼠在体单向灌流法,用HPLC测定金蒿滴丸中一枝蒿酮酸和金丝桃苷在肠道不同部位的吸收情况,同时考察P-gp抑制剂维拉帕米和ATP抑制剂叠氮化钠对大鼠肠吸收的影响。结果一枝蒿酮酸和金丝桃苷在大鼠小肠上端吸收较好。维拉帕米显著降低了金丝桃苷在小肠上端的吸收(P<0.05),对一枝蒿酮酸的吸收没有显著影响;叠氮化钠显著降低了一枝蒿酮酸在小肠上端吸收(P<0.01),同时也显著性抑制了金丝桃苷在四个肠段的吸收(P<0.01)。结论金蒿滴丸有效成分一枝蒿酮酸和金丝桃苷在大鼠肠道内吸收较好。
AIM To study the rat＇s intestinal absorption behavior of two active components of rupestonic acid （Ra） and hyperoside （Hp） in Jinhao Kangliugan Dropping Pills. Methods In situ single-pass intestinal perfu- sion method was used to perform the intestinal absorption in rat and measure Ra and Hp by HPLC, and the effects of P-gp inhibitor （verapamil） and ATP inhibitor （sodiumazide） on absorption of Ra and Hp were determined. Re- suits The absorption of Ra and Hp from Jinhao Rangliugan Dropping Pills in upper part of small intestinal was bet- ter than the other segments Verapamil had remarkable effect on absorption of Hp （P 〈 0.05 ）. Sodiumazide lowered the absorption of Ra into upper part of swall intestinal （P 〈0. 01 ）, and reduced the absorption of Hp into total in- testinel （P 〈0. 01 ）. Conclusion The active components Ra and Hp from Jinhao Kangliugan Dropping Pills have good intestinal absorptive behavior
出处
《中成药》
CAS
CSCD
北大核心
2013年第11期2372-2378,共7页
Chinese Traditional Patent Medicine
基金
国家科技重大专项"重大新药创制"课题(2011ZX09102-009-07)
关键词
肠吸收
单向灌流模型
金蒿抗流感滴丸
一枝蒿酮酸
金丝桃苷
intestinal absorption
single-pass perfusion model
Jinhao Kangliugan Dropping Pills
rupestonic acid
hyperoside
