摘要
目的 :比较益气健脾法与益气健脾祛痰化瘀法对D -半乳糖 (D - gal)所致衰老小鼠自由基的影响。方法 :测定D -gal诱导的亚急性衰老小鼠血清、心、肝组织中总超氧化物歧化酶 (T -SOD)活性 ;心、肝组织中丙二醛 (MDA)、脂褐素 (LPF)水平 ,并观察益气健脾及益气健脾祛痰化瘀方药对上述指标的影响。结果 :益气健脾及益气健脾祛痰化瘀方药能不同程度地提高D- gal致衰老模型小鼠血清、心、肝组织中T -SOD的活性 ,降低心、肝组织MDA、LPF含量。结论 :抑制脂质过氧化反应 ,提高抗氧化酶活性可能是益气健脾法及益气健脾祛痰化瘀法延缓衰老的共同作用机制之一 。
Objective: To observe the influence of method of replenishing qi to invigorate the spleen and method of replenishing qi to invigorate the spleen and eliminating phlegn and removing blood stasis on the free radical of modelled mice. Methods: To examine the T-SOD activity of blood serum, heart and liver tissues of subacute senile mice caused by D-gal, to detect the MDA and LPF level of heart and liver tissues; and to observe the influence of prescriptions for replenishing qi to invigorate the spleen and eliminating phlegm and removing blood stasis on the above indexes. Result: The prescriptions for replenishing qi to invigorate the spleen and eliminating phlegm and removing blood stasis can improve the T-SOD activity of blood serum, heart and liver tissues of modelled senile mice and decrease the MDA and LPF quantity of heart and liver tissues. Conclusion: To restrain the lipid peroxidation to improve the activity of antioxidase may be one of the combined action mechanism of the two methods in delaying senility.
出处
《河南中医》
2004年第11期20-22,共3页
Henan Traditional Chinese Medicine
基金
河南省科委科技攻关资助项目 (No .0 32 4 4 10 0 4 2 )
关键词
益气健脾
益气健脾祛痰化瘀
衰老
脂质过氧化
抗氧化酶
小鼠
replenishing qi to invigorate the spleen
replenishing qi to invigorate the spleen and eliminating phlegn and removing blood stasis
senility
peroxidation
antioxidase
mouse
