摘要
儿茶素对ＡＤＰ，ＡＡ和胶原诱导家兔的体外血小板聚集有明显的抑制作用，随着剂量的增加，这种抑制作用逐渐增强；儿茶素以２００和４００ｍｇ／ｄａ的剂量大鼠灌胃给药，连续１４ｄ，对ＡＤＰ诱导的血小板聚集作用亦有显著的抑制作用，并呈剂量依赖关系。在实验性血栓形成实验中，儿茶素显著地抑制大鼠血栓形成，放射免疫方法测定发现用儿茶素２００和４００ｇ／ｋｇ·ｄ－１灌胃给药，连续给药８ｄ，显著降低了大鼠血浆Ｔ×Ａ２含量，但对６－ｋｃｔｏ－ｐＧＦ１０含量没有明显影响，提示儿茶素和阿斯匹林作用机制可能不同。
he effect of catechin on the ADP,AA and Collagen-induced aggregation of vabbit
plateletswas examined in vitro,the results showed that platelet aggregation was significantly
inhibited andthe effect was dose-dependent. At the dose of ig 200 and 400 mglkgd“-for 14
days,catechinstrongly inhibited ADp-induced aggregation of rat platelets in vivo. In the other
test,catechinsuppressed the thrombosis. By the tadio-immuno assay,it was found that i.g. 200
and 400 mg/kg·d-1 for 8 days,catechin lowered the content of TXA2 remarkably in rats plasma
but it didntchange the concentration 6-keto-pGFIa. It is suggested the the active machanism of
catechin maybe different from that of aspirin.
出处
《南京铁道医学院学报》
1994年第1期12-14,共3页
Journal of Nanjing Railway Medical College
