摘要
目的探讨Ⅱ型糖尿病 (NIDDM)患者的血管性假血友病因子 (vWF)、血小板α颗粒膜蛋白 -140(GMP -140)、D -二聚体 (D -D)、抗凝血酶Ⅲ (AT-Ⅲ )、组织纤溶酶原激活物 (t-PA)血浆含量对血管合并症的影响。方法将265例NIDDM患者分成两组 ,一组 (113例 )无血管合并症 ,另一组 (152例 )有血管合并症。对每个患者进行上述5种血栓分子标志物含量的检测 ,并与40例健康人进行对照。结果NIDDM患者不论有无血管合并症 ,血浆vWF、GMP -140、D -D均高于健康对照组 (P均<0.001) ,AT-Ⅲ、t-PA则低于健康对照组 (P均<0.001) ;有血管合并症组与无血管合并症组相比 ,vWF、GMP -140、D -D升高更为明显 (P均<0.001) ,而AT-Ⅲ、t-PA更显著降低。结论这5种血栓分子标志物作为综合因素 ,使NIDDM患者血液处于高凝状态 ,内皮细胞功能障碍 ,血小板高活化与继发性纤溶亢进。检测这5种血栓分子标志物有助于早期发现NIDDM患者血栓前状态与血管病变 。
Objective To study the plasma levels of von willebrand factor(vWF),alpha granule membrane protein140(GMP_140),D_Dimer(D_D),fibrinogen,anti_thrombinⅢ(AT_Ⅲ)and tissue plasminogen activator(t_PA)in patients with diabetes typeⅡ(NIDDM)and to study its clinical significance.Methods265patients with NIDDM(113without vascular complication and152with)were tested the plasma levels of5thrombus molecular markers and the results were compared with those in40normal controls.Results The levels of vWF、GMP_140and D_D in patients were higher than those of normal controls and the levels of AT_Ⅲand t_PA in paˉtients were lower than those of normal controls(P<0.001);The levels of vWF、GMP_140and D_D in NIDDMwith vascular complication were superior to those in NIDDMwithout vascular complication,but AT_Ⅲand t_PA contents were just the reverse(P<0.001).Conclusion The detection of plasma levels of five thrombus molecular markers has an important value in early diagnosis and treatment of diabetic vascular complication.
出处
《广西预防医学》
2004年第5期264-266,共3页
Guangxi Journal of Preventive Medicine
基金
广东省佛山市医药卫生基金资助课题 (2001-268)
