摘要
目的 :检测血管内皮生长因子(vascularendothelialgrowthfactor ,VEGF)和基质金属蛋白酶 -2 (matrixmetalloproteinase 2 ,MMP 2 )在大肠癌组织中的表达及其与肿瘤进展的关系。方法 :应用免疫组化SP法检测了 18例正常大肠黏膜、18例大肠腺瘤样息肉和 5 1例大肠癌组织中VEGF、MMP 2的表达。结果 :大肠腺瘤样息肉、大肠癌中VEGF、MMP 2阳性表达率显著高于正常大肠黏膜组织 ,P <0 0 5。VEGF、MMP 2阳性表达率与大肠癌的淋巴结转移、Duke’s分期有关 ,P <0 0 5。VEGF、MMP 2在大肠癌中的表达有相关性 ,P<0 0 5。结论 :VEGF、MMP
OBJECTIVE:To observe the expressions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in colorectal carcinoma and their relationships with progression.METHODS: The expressions of VEGF and MMP-2 in 18 cases of normal colorectal mucosa, 18 cases of colorectal adenomatous polyp and 51 cases of colorectal carcinoma were determined by SP technique of immunohistochemical staining with antibodies against VEGF, MMP-2.RESULTS: The positive rates of the expressions of VEGF and MMP-2 in colorectal adenomatous polyp group and colorectal carcinoma group were higher than those in normal mucosa group,respectively,P<0.05. The positive rates of VEGF and MMP-2 were related with lymph node metastasis and Dukes’ stages of colorectal carcinoma,P<0.05. The expression of VEGF was positively correlated with the expression of MMP-2 in colorectal carcinoma,P<0.05.CONCLUSION: Both VEGF and MMP-2 may serve as predictors of progression in colorectal carcinoma and potential targets for therapy of colorectal carcinoma.
出处
《肿瘤防治杂志》
CAS
2004年第8期841-843,共3页
China Journal of Cancer Prevention and Treatment
