摘要
目的 研究利多卡因凝胶的经皮吸收动力学以及药效学。方法 用经皮微渗析的方法测定大鼠真皮内药物浓度的变化 ,计算相关参数 ;用电刺激法考察药效 ,并与市售EMLA(eutecticmixtureoflocalanesthetics)霜剂进行药效比较。结果 持续用药 1h ,利多卡因经皮吸收动力学曲线在 1 2 5h达到峰值 ;起效时间与EMLA霜剂相近 ,局麻作用维持时间和局麻强度优于EMLA。结论 利多卡因凝胶具有良好的局麻作用 ;局部用药后 ,利多卡因产生局部麻醉作用的真皮中最低有效浓度为 12mg·L- 1 。
Aim To study the cutaneous permeation kinetics and pharmacodynamics of lidocaine gel. Methods The concentration of lidocaine in dermis following topical application in rats was determined by the cutaneous microdialysis technique and related parameters were calculated; the pharmacodynamics of the gel was evaluated by electric stimulation method with EMLA (eutectic mixture of local anesthetics) cream as a control. Results The peak of percutaneous absorption kinetic profile of lidocaine gel across rat skin ...
出处
《药学学报》
CAS
CSCD
北大核心
2003年第8期631-633,共3页
Acta Pharmaceutica Sinica
关键词
利多卡因
凝胶
经皮微渗析
药效学
lidocaine
gel
cutaneous microdialysis
pharmacodynamics
