摘要
利多卡因和普鲁卡因与河琢毒素(TTX)EC_5合用于小鼠坐骨神经麻醉,其EC_(50)均比它们单用为低(P<0.05,P< 0.01),且麻醉持续时间明显延长;在家兔硬膜外麻醉中,合用与单用的EC_(50)未见显著差异,但均延长麻醉持续时间;在家兔角膜麻醉中,利多卡因与TTX合用,其EC_(50)比单用利多卡因低(P<0.05),而普鲁卡因与TTX合用的EC_(50)与单用普鲁卡因无显著性差异。两药与TTX(EC_5)合用的LD_(50)(小鼠)均与单用无显著差异,但可提高它们的治疗指数。
<ABSTRACT> In sciatic nerve anesthesia in mouse. EC_(50) produced by combinations oflidocaine or procaine with TTX(EC_5)Were markedly lower than that obtaiuedwith them alone, the durations of lccal anesthetics action were also much longer. There was no significant difference observed between the EC_(50) of thelocal anesthetics alone and that resulted from combinations with TTX(EC_5)in peridural anesthesia in rabbit. but the durations of action induced by combined administration were markedly longer.ln cornea anesthesia in rabbit,the EC_(50) obtained with combination of lidocaine with TTX(EC_5) was muchsmaller than that produced by it alone, but the EC_(50) of combination of procaine with TTX(EC_5) was not different from that induced by it alone. he LD_(50) of combinations of them with TTX(EC_5) and that of themselves were not significantly different.
关键词
局麻作用
毒性
硬膜外麻醉
坐骨神经麻醉
角膜麻醉
河豚毒素
小鼠
家兔
方法
local aresthetic activity
toxicity
peridural anesthesia
sciatic nerve anesthesia
cornea anesthesia
tetrodotoxin
mouse
rabbjt:method
