摘要
近年来的研究表明,肿瘤微环境相较正常组织明显不同,如酶表达异常、缺氧、pH改变等。肿瘤微环境与肿瘤细胞的诱导增殖、新生血管的生成、免疫逃逸以及多药耐药的产生息息相关。肿瘤相关成纤维细胞(CAF)是肿瘤微环境中的主要基质细胞类型,其分泌的多种细胞因子在肿瘤的生长、侵袭和转移中起到了重要的作用。了解CAF在乳腺癌发生发展中的作用及其机制,有望为改善乳腺癌患者的预后提供新的作用靶点。
Recent studies have shown that tumor microenvironment(TME)is significantly different from normal tissues,such as the change of abnormal enzyme expression,hypoxia,pH and so on.TME is closely related to the induced proliferation of tumor cells,angiogenesis,immune escape and the production of multidrug resistance.Cancer associated fibroblasts(CAFs)are the main stromal cell types in the TME.A variety of cytokines secreted by CAFs play an important role in tumor growth,invasion and metastasis.Understanding the role and mechanism of CAFs in the development of breast cancer is expected to provide a new target for improving the prognosis of breast cancer patients.
作者
王文浩
孙希瑞
刘锦
孙秀梅
Wang Wenhao;Sun Xirui;Liu Jin;Sun Xiumei(Department of Oncology,Affiliated Hospital of Weifang Medical University,Weifang 261041,China;Clinical Research Center,Affiliated Hospital of Weifang Medical University,Weifang 261041,China)
出处
《国际肿瘤学杂志》
CAS
2022年第10期615-618,共4页
Journal of International Oncology
基金
山东省医药卫生科技发展计划(202103100528)
关键词
肿瘤微环境
癌相关成纤维细胞
乳腺肿瘤
外泌体
Tumor microenvironment
Cancer-associated fibroblasts
Breast neoplasms
Exosomes
