摘要
缺氧和酸中毒、间质压力增加、细胞外基质结构和功能的变化、生长因子和蛋白水解酶的产生、血管新生和免疫炎性反应都是促进肿瘤存活和转移的微环境。动物模型在研究肿瘤微环境的病理、生理变化中发挥重要作用，文章就动物模型在肿瘤微环境研究中的进展进行综述。
Hypoxia and localized acidosis, increased interstitial pressure, perturbations in structure and function of the extracellular matrix, the production of growth factors and protein hydrolase, angiogenesis, and co-optation of the immune response are all microenvironment that promote tumor survival and metastasis. The application of animal models is critical to the understanding of the pathophysiology in these processes. This review will show the advances of animal models in the study of tumor microenvironment.
出处
《肿瘤研究与临床》
CAS
2015年第12期854-857,共4页
Cancer Research and Clinic
基金
国家自然科学基金青年项目（81402377）
关键词
动物模型
肿瘤微环境
病理生理
Animal models
Tumor microenvimnment
Pathophysiology
