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Association Between rs1815739 Polymorphism of ACTN3 Gene and Athletic Ability in Chinese Sprinters

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摘要 Purpose The aim of this study was to investigate the prevalence of the ACTN3 rs1815739 polymorphism and to study its association with athletes'level of competition and lower-extremity power.Method Time-of-flight mass spectrometry(TOFMS)and polymerase chain reaction-restriction fragment length polymor-phism(PCR-RFLP)techniques were employed to identify the ACTN3 rs1815739 genotypes and allele frequencies in 108 elite sprinters and 206 untrained controls.Questionnaires were then used to assess subjects'100 m sprint,standing jump(SJ)and standing triple jump(STJ)personal best record.Results(1)The RR,RX and XX genotype distribution of the ACTN3 rs1815739 polymorphism is 42.6%,49.1%,8.3%,respectively.R and X alleles frequency is 67.1%and 32.9%,respectively,which comply with Hardy Weinberg equilibrium(HWE)through Chi-square(x2)tests(x2=0.661;df=2;P=0.718).(2)Significant differences were found in R allele fre-quency between the elite sprinter group and controls.(3)The athletes'100 m sprint,SJ,and STJ personal best records were better in those with RR and RX than XX genotype.A significant association was observed between the R alleles and 100 m sprint,SJ,and STJ results of male and female athletes.Conclusion The present results indicate that ACTN3 rs1815739 polymorphism has a significant association with speed and lower-extremity power in sprint/power athletes.
出处 《Journal of Science in Sport and Exercise》 2020年第2期113-119,共7页 体育运动科学(英文)
基金 supported by Fundamental Research Funds for the Central Universities under Grant 2017SYS001.
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