摘要
探索ACTN3基因rs1815739位点多态性与体质指数(BMI)之间的关系。应用实时荧光定量PCR法检测ACTN3基因rs1815739位点基因型,测量RR,RX,XX基因型女大学生身高和体重,计算出体质指数,采用单因素方差(One-Way ANOVA)分析ACTN3基因rs1815739位点基因型与年龄和体质指数间的关系。女大学生ACTN3基因RR,RX,XX基因频率分别为39.48%,49.12%,11.4%,经Hardy-Weinberg平衡检验具有群体代表性(P>0.05),RR,RX,XX基因型平均年龄分别为22.84±1.49岁,22.73±1.52岁,22.68±1.37岁(P>0.05),但RR,RX,XX不同基因型间BMI分别为21.48±2.37,23.52±2.84,21.57±2.33(P<0.05)。ACTN3基因rs1815739位点多态性与女大学生体质指数有关,该因素可能为导致体质指数差异的内在原因之一。
To explore the relationship between ACTN3 gene rs1815739 polymorphism and Body Mass Index （BMI）, ACTN3 gene rs1815739 locus polymorphism were detected by real-time fluorescence quantitative PCR, RR, RX, XX genotype of female college students, whose height and weight were measured and was Body Mass Index calculated. To analyze the relationship between ACTN3 gene rs1815739 locus genotype age and Body Mass Index by One-Way ANOVA. The ACTN3 gene RR, RX, XX allele frequency were 39. 48%, 49. 12%, 11.4%, the hardy-Weinberg equilibrium test has a representative group （ P 〉 0. 05 ）, the average age of RR, RX, XX genotype were 22. 84 ± 1.49 years, 22. 73±1.52 years, 22. 68 ±1.37 years old （P 〉 0.05） , but BMI of RR, RX, XX different genotype were respectively 21.48 ± 2. 37, 23.52 ±2.84 and 21.57 ±2.33 （P 〈0. 05）. The rs1815739 locus polymorphism of ACTN3 gene was related to the Body Mass Index of the female college students, which may be one of the internal reasons for the differences in Body Mass Index.
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第6期857-860,共4页
Journal of Northwest University（Natural Science Edition）
基金
陕西省社会发展攻关计划基金资助项目(2011K12-01-05)
陕西省高等教育教学改革研究基金资助项目(2015-56)
陕西省体育局常规课题基金资助项目(15019)
