摘要
目的探讨分化型甲状腺癌(DTC)术后患者^(131)I治疗后全身显像(Rx-WBS)中肝脏弥漫性摄取(DHU)的临床意义。方法回顾性分析178例DTC,根据Rx-WBS所示DHU程度将其分为G0组(n=41)、G1组(n=69)、G2组(n=56)和G3组(n=12);将P<0.2的因素纳入有序Logistic回归分析,筛选DHU影响因素。结果178例DTC中,137例(137/178,76.97%)可见DHU。单因素分析显示4组患者促甲状腺激素(TSH)、^(131)I剂量及远处转移(M)差异均有统计学意义(P均<0.05),而年龄、甲状腺球蛋白(Tg)等11个因素差异均无统计学意义(P均>0.05)。多因素有序Logistic回归分析显示^(131)I剂量(β=0.013,P=0.036)是DHU程度的独立影响因素;4组间TSH、M、治疗次数及Tg差异均无统计学意义(P均>0.05)。结论^(131)I剂量是DHU程度的独立影响因素,且具有显著正向影响。
Objective To explore the clinical significance of diffuse hepatic uptake(DHU)in^(131)I post-therapy whole body scan(Rx-WBS)of patients with differentiated thyroid carcinoma(DTC)after surgical resection.Methods Data of 178 DTC patients after surgical resection were retrospectively analyzed.According to the degrees of DHU in Rx-WBS,the patients were divided into group G0(n=41),group G1(n=69),group G2(n=56)and group G3(n=12),respectively.The factors with P<0.2 were put into orderly Logistic regression analysis to explore the impact factors of the degrees of DHU.Results Totally 137 patients(137/178,76.97%)were found with DHU.Single factor analysis showed that there were significant differences of thyroid stimulating hormone(TSH),^(131)I dose and distant metastases(M)among 4 groups(all P<0.05),but not of age,thyroglobulin(Tg)nor other 11 factors(all P>0.05).Orderly Logistic regression analysis showed that^(131)I dose(β=0.013,P=0.036)was an independent impact factor of DHU degree,while no statistical difference of TSH,M,times of treatment nor Tg was detected(all P>0.05).Conclusion^(131)I dose was an independent impact factor of DHU degree,which had significant positive effect on the degree of DHU.
作者
罗玲玲
汪世存
姚晓波
金晓毛
张然
夏俊勇
卞岍雨
LUO Lingling;WANG Shicun;YAO Xiaobo;JIN Xiaomao;ZHANG Ran;XIA Junyong;BIAN Qianyu(Department of Nuclear Medicine,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230002,China)
出处
《中国医学影像技术》
CSCD
北大核心
2021年第7期1020-1024,共5页
Chinese Journal of Medical Imaging Technology
