摘要
目的:探讨血清长链非编码RNA小核RNA宿主基因1(lncRNA SNHG1)与急性ST段抬高型心肌梗死(STEMI)患者冠状动脉支架内再狭窄(ISR)的相关性。方法:选取2020年1月至2021年5月于本院心血管内科接受择期经皮冠状动脉介入(PCI)治疗的150例STEMI患者。依据是否发生ISR分为ISR组(28例)和非ISR组(114例),失访8例。采用实时荧光定量PCR测定血清lncRNA SNHG1水平,并收集患者临床资料。结果:与非ISR组比较,ISR组患者吸烟率、合并糖尿病率、TC水平、LDLC水平及TBIL水平均显著增高(P<0.05),血清lncRNA SNHG1相对表达量显著降低(P<0.05)。ROC曲线结果显示,血清lncRNA SNHG1预测STEMI患者支架内再狭窄的临界值为0.95,AUC为0.863(95%CI:0.764~0.962),灵敏度为70.18%,特异度为89.29%。与lncRNA SNHG1高水平者相比,lncRNA SNHG1低水平者ISR发生率较高(P<0.05),无再狭窄平均时间较短(P<0.05)。结论:血清lncRNA SNHG1对ISR具有一定预测价值,低水平lncRNA SNHG1是STEMI患者PCI术后ISR的危险因素。
Objective:To investigate the correlation between serum long non-coding RNA small nucleolar RNA host gene 1(lncRNA SNHG1)and in-stent restenosis(ISR)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods:150 patients with STEMI who received selective percutaneous coronary intervention(PCI)in the cardiovascular department of our hospital from January 2020 to May 2021 were selected.According to whether ISR occurred or not,the patients were divided into ISR group(28 cases)and non-ISR group(114 cases),with 8 cases lost to follow-up.The level of serum lncRNA SNHG1 was measured by real-time fluorescence quantitative polymerase chain reaction(RT-qPCR)and the clinical data of patients were collected.Results:Compared with non-ISR group,the smoking rate,diabetes rate,TC level,LDLC level and TBIL level in ISR group significantly increased(P<0.05),and the level of serum lncRNA SNHG1 relative expression significantly decreased(P<0.05).ROC curve results showed that serum lncRNA SNHG1 predicted intrastent restenosis in STEMI patients with a critical value of 0.95,AUC of 0.863(95%CI:0.764-0.962),sensitivity of 70.18%,and specificity of 89.29%.The incidence of ISR in patients with lncRNA SNHG1 low level was higher than that in patients with lncRNA SNHG1 high level(P<0.05),and the mean time without restenosis was shorter(P<0.05).Conclusion:Serum lncRNA SNHG1 has a certain predictive value for ISR,and low lncRNA SNHG1 level is a risk factor of ISR after PCI in patients with STEMI.
作者
韦颖
莫昌干
花冠杰
赖冬艳
韦利元
Wei Ying;Mo Changgan;Hua Guanjie;Lai Dongyan;Wei Liyuan(Department of Cardiology,The People's Hospital of Hechi,Hechi 547000,China)
出处
《广西医科大学学报》
CAS
2023年第3期477-481,共5页
Journal of Guangxi Medical University
基金
右江民族医学院2021年度校级科研课题(No.yy2021sk111)
