摘要
目的分析急性冠状动脉综合征(ACS)患者经皮冠状动脉介入术(PCI)后血清microRNA-224(miR-224)水平的变化及其与支架内再狭窄的关系。方法选取2016年1月—2018年12月接受治疗的212例ACS患者作为研究对象。根据是否发生支架内再狭窄将其分为狭窄组(n=42)和非狭窄组(n=170)。采用实时荧光定量PCR检测ACS患者血清miR-224水平,并分析其与支架内再狭窄的关系。结果212例ACS患者接受PCI治疗1年内有42例(19.81%)发生支架内再狭窄。狭窄组低密度脂蛋白胆固醇(LDLC)、糖尿病比例和支架长度均高于非狭窄组,差异均有统计学意义(P<0.05)。两组血清miR-224水平随时间进展呈升高趋势,狭窄组PCI术后7天miR-224水平低于非狭窄组,差异有统计学意义(P<0.05)。PCI术后7天miR-224水平评价ACS患者支架内再狭窄的AUC为0.860,高于术后1天miR-224和术后3天miR-224(P<0.05)。Logistic多因素回归分析结果显示LDLC、糖尿病、支架长度和PCI术后7天miR-224水平与ACS患者支架内再狭窄密切相关(P<0.05)。结论miR-224水平与ACS患者PCI术后1年支架内再狭窄关系密切。ACS患者PCI术后7天血清miR-224水平低提示支架内再狭窄风险较高。
Aim To analyze the changes of serum microRNA-224(miR-224)level after percutaneous coronary intervention(PCI)in patients with acute coronary syndrome(ACS)and its relationship with in-stent restenosis.Methods A total of 212 patients with ACS who were treated from January 2016 to December 2018 were selected as study subjects.They were divided into two groups based on the occurrence of in-stent restenosis:stenosis group(n=42)and non-stenosis group(n=170).The serum miR-224 level of ACS patients was detected by real-time quantitative PCR,and the relationship between miR-224 level and in-stent restenosis was analyzed.Results In 212 patients with ACS who underwent PCI treatment,42 patients(19.81%)developed in-stent restenosis within 1 year.The low density lipoprotein cholesterol(LDLC),the proportion of diabetes and the length of the stent were higher in the stenosis group than those in the non-stenosis group,and the differences were statistically significant(P<0.05).The level of serum miR-224 in the two groups showed an increasing trend with time.The 7-day miR-224 level was lower in the stenosis group than that in the non-stenosis group,and the difference was statistically significant(P<0.05).The 7-day miR-224 assessment of in-stent restenosis in patients with ACS was 0.860,which was higher than the 1-day miR-224 and the 3-day miR-224(P<0.05).Logistic multivariate regression analysis showed that LDLC,diabetes,stent length,and 7-day miR-224 level were closely related to in-stent restenosis in ACS patients(P<0.05).Conclusion The level of miR-224 is closely related to in-stent restenosis at 1 year after PCI in patients with ACS.A low serum miR-224 level at 7 days after PCI in patients with ACS indicates a higher risk of in-stent restenosis.
作者
杜丹
董利平
DU Dan;DONG Liping(Department of Geriatrics,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《中国动脉硬化杂志》
CAS
2021年第4期317-321,共5页
Chinese Journal of Arteriosclerosis
基金
河北省卫健委医学科学研究课题计划项目(20200560)。
