摘要
肠外营养(PN)为不能经肠内喂养获得充足营养物质的病人提供了营养支持,在临床应用中至关重要。但长期PN的病人会出现如导管相关血流感染、肝功能受损等诸多并发症,其发生机制的根源之一是PN引起的肠屏障功能损伤。近年来相关研究众多,本文对PN引起肠屏障功能受损的机制及其在肠外营养相关肝损伤(PNALD)发生发展中的作用做一综述。
Parenteral nutrition(PN)isalifesaving method for adults or children who cannot be provided with sufficient nutrients enterally,and is crucial in clinical practice.However,long-term PN may lead to many complications such as catheter-related bloodstream infectionsand impaired liver function.It is considered that intestinal barrier dysfunction caused by PN is one of the majormechanisms involved in these complications.There have been many studies recently in such field.This paper reviewed the mechanism of intestinal barrier dysfunction caused by PN and its role in the development of parenteral nutrition-associated liver disease(PNALD).
作者
刘坤慧
颜伟慧
蔡威
LIU Kun-hui;YAN Wei-hui;CAI Wei(Department of Pediatric Surgery,Xinhua Hospital,Shanghai Jiaotong University Medical School,Shanghai 200092,China)
出处
《肠外与肠内营养》
CAS
CSCD
北大核心
2022年第6期370-374,共5页
Parenteral & Enteral Nutrition
基金
上海市卫生系统重要薄弱学科建设(2019ZB0101)
上海市临床重点专科建设项目(shslczdzk05702)
上海市科委基于长三角同质化小儿消化道畸形防治体系研究(19495810500)
上海申康医院发展中心临床创新三年行动计划资助(SHDC2020CR2010A)
关键词
肠外营养
肠外营养相关性肝损伤
肠屏障功能
肠上皮细胞
肠道菌群
Parenteral nutrition
Parenteral nutrition-associated liver disease
Intestinal barrier
Intestinal epithelial cell
Intestinal microbiota
