摘要
目的 研究银耳多糖吸收、分布的特征。方法 同位素标记、凝胶柱层析等。结果 银耳多糖 (Tp)口服后仅有微量 (约0 .4 % )通过胃肠道入血 ,被器官所吸收。进入血液中的Tp 分子量未见明显变化 ,口服给药和静脉给药的器官分布结果相似 ,绝大部分在肝、肾中。在肝脏中 ,主要为KC所摄取。结论 静脉给药后 ,Tp 在血中清除的速率较慢 ,绝大部分由肾脏排出体外 ,但排入尿中的Tp 分子量改变不明显。
OBJECTIVE To study the characteristics of absorption, distribution and clearance of Tremella polysaccharide.METHODS The isotopic labelling and gel filtration chromatography were used.RESULT Tremella polysaccharide(T p), isolated from Tremella fuciformis Berk, was absorbed into blood about 0.4% only and then was distributed into organs and tissues after it was administered orally.The molecular weight of T p in blood was not changed obviously.The distribution in organs of T p after po or iv administration was same,mainly,in liver and kidney.T p in liver was taken up by KC mainly.CONCLUSION T p was cleared slowly from blood after iv injection from kidney.The molecular weight of T p in urine was changed unobviously compared with original Tp.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2002年第3期205-208,共4页
Chinese Pharmaceutical Journal
基金
国家科委重点科技攻关项目 (96-90 1-0 6-68)
