摘要
目的探讨吲哚布芬联合氯吡格雷对急性缺血性脑卒中患者神经功能及抗血小板聚集效果的影响。方法选取河南省第二人民医院2020年3月至2022年3月收治的102例急性缺血性脑卒中患者为研究对象。按照随机数字表法分为对照组与观察组,每组51例。对照组口服氯吡格雷片治疗,观察组在对照组治疗基础上加服吲哚布芬治疗,两组均持续治疗14 d。比较两组临床疗效、神经功能[美国国立卫生研究院卒中量表(NIHSS)]、抗血小板聚集效果[二磷酸腺苷诱导的血小板最大聚集率(MAR-ADP)、花生四烯酸诱导的血小板最大聚集率(MAR-AA)]、血液流变学指标及不良反应。结果治疗后,观察组治疗总有效率(96.08%,49/51)较对照组高(82.35%,42/51),差异有统计学意义(χ^(2)=4.993,P=0.026<0.05)。治疗前,两组神经功能比较,差异未见统计学意义(P>0.05);治疗后,两组NIHSS评分均较治疗前低,且观察组较对照组低(P<0.05)。治疗前,两组抗血小板聚集效果比较差异未见统计学意义(P>0.05);治疗后,两组MAR-ADP、MAR-AA均较治疗前低,且观察组较对照组低(P<0.05)。治疗前,两组血液流变学指标比较,差异未见统计学意义(P>0.05);治疗后,两组全血高切黏度、全血低切黏度、纤维蛋白原均较治疗前低,且观察组较对照组低(P<0.05)。对照组不良反应发生率(9.80%,5/51)与观察组(13.73%,7/51)比较,差异未见统计学意义(χ^(2)=0.378,P=0.539>0.05)。结论吲哚布芬联合氯吡格雷治疗急性缺血性脑卒中效果确切,能够减轻神经功能损伤,增强抗血小板聚集效果,改善血液流变学,且安全性高。
Objective To investigate the effect of indobufen combined with clopidogrel on nerve function and anti-platelet aggregation in patients with acute ischemic stroke.Methods A total of 102 patients with acute ischemic stroke admitted to the Second People’s Hospital of Henan Province from March 2020 to March 2022 were selected as the study subjects.According to the method of random number table,they were divided into control group and observation group,with 51 cases in each group.The control group was treated with clopidogrel tablets,and the observation group was treated with indobufen on the basis of the control group,Both groups were treated for 14 days.The clinical efficacy,neurological function(NIHSS),antiplatelet aggregation effect[maximum platelet aggregation rate induced by adenosine diphosphate(MAR-ADP),maximum platelet aggregation rate induced by arachidonic acid(MAR-AA)],hemorheology indexes and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of treatment in the observation group(96.08%,49/51)was higher than that in the control group(82.35%,42/51),the difference was significant(χ^(2)=4.993,P=0.026<0.05).Before treatment,there was no significant difference in nerve function between the two groups(P>0.05).After treatment,the NIHSS scores of the two groups were lower than that before treatment,and that of the observation group was lower than that of the control group(P<0.05).Before treatment,there was no significant difference in antiplatelet aggregation effect between the two groups(P>0.05).After treatment,MAR-ADP and MAR-AA in the two groups were lower than those before treatment,and those of the observation group was lower than those in the control group(P<0.05).Before treatment,there was no significant difference in hemorheology between the two groups(P>0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and fibrinogen in the two groups were lower than those before treatment,and those in the observation group w
作者
张振岭
Zhang Zhenling(Department of Neurology,the Second People’s Hospital of Henan Province,Xinzheng 451191,China)
出处
《临床医学》
CAS
2023年第2期104-107,共4页
Clinical Medicine
