摘要
目的研究MRI灌注加权成像(perfusion weighted imaging,PWI)对症状性卒中患者脑缺血区域血流灌注及侧支循环建立评价的临床价值。材料与方法选取2018年8月至2019年8月前来就诊具有症状性脑卒中患者80例,均先行常规MRI检查,对扩散加权成像(diffusion weighted imaging,DWI)结果为阴性的患者再行MRI-PWI成像,测量分析患侧与健侧的局部脑血容量(reginal cerebral blood volume,rCBV)、局部脑血流量(reginal cerebral blood flow,rCBF)、平均通过时间(mean transit time,MTT)、最大峰值时间(time to peak,TTP)数值及时间-密度曲线。结果在29例DWI结果为阴性的患者中,有25例脑内存在异常灌注区域,其中Ⅰ1期8例、Ⅰ2期6例、Ⅱ1期5例、Ⅱ2期6例,缺血区域与健侧对比,rCBV、rCBF、MTT、TTP差异具有统计学意义(P<0.05),在Ⅰ2期及Ⅱ1期侧支血管建立良好。结论PWI对早期脑组织低灌注区域的检出率更高,同时可评价周边微血管的状态,为早期缺血性脑卒中患者提供有力的诊断依据。
Objective:To study the clinical value of MRI perfusion imaging in the evaluation of cerebral ischemia perfusion and collateral circulation in symptomatic stroke patients.Materials and Methods:The total of 80 patients with symptomatic stroke were selected from August 2018 to August 2019.All the patients with negative DWI imaging results underwent conventional MRI,and then underwent MRI-PWI.The reginal cerebral blood volume(rCBV),reginal cerebral blood flow(rCBF),mean transit time(MTT),time to peak(TTP)values and time-density curves of the affected and healthy sides were measured and analyzed.Results:In 29 cases of DWI results can be negative patients,25 cases of brain exists abnormal perfusion areas,includingⅠphase 18 cases,6 patients withⅠphase 2,Ⅱphase 1 in 5 cases,Ⅱphase 2 and 6 cases of ischemia area compared with the contralateral,rCBV,rCBF,determined by MTT,TTP differences statistically difference(P<0.05)inⅠphase 2 andⅡphase 1 establish good collateral vessels.Conclusions:PWI has a higher detection rate in the early hypoperfusion area of brain tissue and can evaluate the status of peripheral microvessels,providing a strong diagnostic basis for patients with early ischemic stroke.
作者
郝璐
陈欢
王红
HAO Lu;CHEN Huan;WANG Hong(Department of Imaging,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,China)
出处
《磁共振成像》
CAS
2020年第10期904-907,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81860301)
新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(编号:WJWY-202008)。
关键词
磁共振成像
灌注加权成像
症状性卒中
脑血流灌注
侧支循环
magnetic resonance imaging
perfusion weighted imaging
symptomatic stroke
cerebral perfusion
collateral circulation
