摘要
目的系统评价仅采用手术治疗卵巢未成熟畸胎瘤(immature terotoma,IT)患者的安全性。方法检索Pubmed、The Cochrane Library、Web of Science、CNKI、Wangfang data数据库,搜集仅用手术治疗卵巢纯型IT患者的研究,检索时限1990-01-01至2022-02-16。由4名研究者独立筛选文献,提取资料并评价纳入研究的偏倚风险后,采用STATA软件进行Meta分析。结果最终纳入5篇病例研究和3篇非随机队列研究,201例患者,15例复发。Meta分析结果显示,仅用手术治疗Ⅰ期卵巢纯型IT患者,复发率(95%可信区间)为5.2%(2.0%,9.4%);仅用手术治疗Ⅰ期G_(2)/G_(3)卵巢IT患者,复发率(95%可信区间)为6.1%(0.3%,16.0%)。3例死亡。结论需要更多高质量的研究,明确是否能仅用手术治疗Ⅰ期G_(2)/G_(3)卵巢纯型IT患者。
Objective To systematically evaluate the safety of the only surgical treatment for patients with ovarian immature teratoma(IT).Methods Pubmed,The Cochrane Library,Web of Science,CNKI,WangFang Data were electronically searched to collect studies on the prognostic outcomes of patients with pure ovarian immature teratoma treated only by surgery and followed up strategy from January 1st,1990 to February 16th,2022.Four reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies.Meta-analysis was then performed with STATA software.Results A total of 3 non-randomized cohort studies and 5 case report studies involving 201 patients were included.Most of the patients were in the early stage.twenty-one patients had relapse,and meta-analysis showed that the relapse rate(95%CI)was 5.2%(2.0%,9.4%).In patients with stageⅠG_(2)/G_(3)pure ovarian IT,the relapse rate(95%CI)was 6.1%(0.3%,16.0%).Three patients died.Conclusions More high-quality studies are needed to determine whether patients with stageⅠG_(2)/G_(3)pure ovarian IT can be treated with surgery alone.
作者
刘传丽
刘金龙
陈晓
张岩
陈俊
孙旸
吴思雨
LIU Chuanli;LIU Jinlong;CHEN Xiao;ZHANG Yan;CHEN Jun;SUN Yang;WU Siyu(Department of Obstetrics and Gynecology,Characteristic Medical Center of the Chinese People’s Armed Police Force,Tianjin 300162,China;Department of Obestetrics and Gynecology,The 79th Group Army Hospital of the Chinese People's Liberation Army,Liaoyang 111000,China)
出处
《武警医学》
CAS
2023年第6期461-464,468,共5页
Medical Journal of the Chinese People's Armed Police Force
关键词
卵巢未成熟畸胎瘤
手术
随访
复发
病理分级
META分析
ovarian immature teratoma
surgery
follow up
relapse
pathological grading
meta-analysis
