摘要
目的:评定斑蝥酸钠维生素B6注射液辅助化疗药物治疗方案用于肺癌患者中的效果。方法:选取2019年5月至2022年1月在安阳市人民医院收治的102例肺癌患者,随机分为对照组(51例)与观察组(51例)。对照组患者行常规化疗方案,观察组患者在对照组的基础上行斑蝥酸钠维生素B6注射液,比较两组患者的治疗效果。结果:观察组患者治疗总有效率74.51%(38/51),较对照组的54.90%(28/51)高,差异具有统计学意义(P<0.05)。两组患者治疗后血清癌胚抗原、鳞状上皮细胞癌抗原、细胞角蛋白19片段抗原21-1水平较治疗前低,且观察组患者治疗后血清癌胚抗原、鳞状上皮细胞癌抗原、细胞角蛋白19片段抗原21-1水平较对照组低,差异具有统计学意义(P<0.05)。两组患者治疗后血清血管生成素-2、血管内皮生长因子水平较治疗前低,且观察组患者治疗后血清血管生成素-2、血管内皮生长因子水平较对照组低,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率9.80%(5/51),较对照组不良反应发生率25.49%(13/51)低,差异具有统计学意义(P<0.05)。结论:肺癌患者经斑蝥酸钠维生素B6注射液辅助化疗药物方案治疗后,能促使治疗效果的提高与肿瘤标志物、血管内皮生长因子等水平的改善,且能降低不良反应的发生率。
Objective To evaluate the efficacy of sodium cantharidate and vitamin B6 injection as adjuvant chemotherapy in patients with lung cancer.Methods A total of 102 patients with lung cancer admitted to Anyang People’s Hospital from May 2019 to January 2022 were selected and randomly divided into control group and observation group,with 51 cases in each group.The patients receiving conventional chemotherapy regimen were included in the control group,and the patients receiving sodium cantharidate and vitamin B6 injection assisted chemotherapy regimen were included in the observation group.The therapeutic effect,tumor markers,angiogenesis related indexes,immune function,adverse reactions and other indexes of the two groups were evaluated.Results The total effective rate of observation group was 74.51%(38/51),higher than 54.90%(28/51)of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of serum carcinoembryonic antigen,squamous cell carcinoma antigen and cytokeratin 19 fragment antigen 21-1 in the two groups were lower than those before treatment,and the levels of serum carcinoembryonic antigen,squamous cell carcinoma antigen and cytokeratin 19 fragment antigen 21-1 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of serum angiopoietin-2,vascular endothelial growth factor were lower than those before treatment,and after treatment the levels of serum angiopoietin-2,vascular endothelial growth factor in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 9.80%(5/51),lower than 25.49%(13/51)in the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with lung cancer,sodium cantharidate and vitamin B6 injection assisted chemotherapy regimen can improve the therapeutic effect,improve the levels of tumor mark
作者
宋璐
李红燕
姚渊
贺志爽
王少芳
SONG Lu;LI Hong-yan;YAO Yuan;HE Zhi-shuang;WANG Shao-fang(Anyang People's Hospital,Henan Anyang 455000)
出处
《深圳中西医结合杂志》
2022年第23期75-78,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
肺癌
斑蝥酸钠维生素B6注射液
培美曲塞二钠
Lung cancer
Sodium cantharidate and vitamin B6 injection
Pemetrexed disodium
