摘要
脑卒中后失语症(PSA)是脑卒中后神经功能缺损的重要表现之一,发病率高,严重影响患者的认知功能和沟通能力,并可影响肢体功能恢复,加重神经功能障碍,导致致残率及病死率升高,给患者、家庭及社会带来很大的精神及经济负担。PSA患者语言功能的恢复依赖于损伤区的血流再灌注、缺血组织的血流恢复、神经递质通路的修复、神经网络的重建。积极规范的急性期治疗、二级预防治疗、早期康复治疗是PSA治疗的基础,其中失语的治疗是关键。目前PSA的治疗以药物治疗为主,其疗效尚缺乏大样本随机对照研究的证实。
Post-stroke aphasia(PSA)is one of the important manifestations of neurological deficits after stroke.It has a high incidence,which seriously affects the cognitive function and communication ability of the patients,and can affect the recovery of limb function,aggravate neurological dysfunction,and cause increased disability and mortality,bringing a great spiritual and economic burden to the patients,families and society.The recovery of language function in PSA patients depends on the reperfusion of blood flow in the injured area,the restoration of blood flow in the ischemic tissue,the repair of neurotransmitter pathways,and the reconstruction of neural networks.Active and standardized treatment in the acute phase,secondary preventive treatment,and early rehabilitation are the basis of PSA treatment,and the treatment of aphasia is the key.At present,the treatment of PSA is mainly drug therapy,and its efficacy is still lacking the validation of large-sample randomized controlled studies.
作者
于晓辉
梁志刚
YU Xiaohui;LIANG Zhigang(Clinical College of Binzhou Medical College,Binzhou 264003,China;Department of Neurology,Chengyang District People′s Hospital of Qingdao City,Qingdao 266000,China;Department of Neurology,Yantai Yuhuangding Hospital,Qingdao University,Yantai 264000,China)
出处
《医学综述》
2021年第3期513-518,共6页
Medical Recapitulate
基金
烟台市科技计划项目(2018SFGY092)。
关键词
脑卒中
失语症
语言康复训练
药物治疗
循证证据
Stroke
Aphasia
Speech function rehabilitation
Drug treatment
Evidence-based evidence
