摘要
目的探讨肺结核患者血清降钙素原(PCT)、C反应蛋白(CRP)、可溶性程序性死亡配体1(s PD-L1)水平及检测意义。方法选取2015年1月-2017年1月在南京市胸科医院治疗的肺结核患者132例,其中涂阳或痰培养阳性54例,涂阴或痰培养阴性78例;同时选取社区获得性肺炎(CAP)患者110例,健康体检者100人作为对照,检测血清PCT、CRP、s PD-L1水平。结果肺结核患者血清PCT、CRP和s PD-L1分别为(0.38±0.12)ng/ml、(4.80±1.12)mg/L和(5.44±1.03)ng/ml,明显高于健康体检者(P<0.05),但低于CAP患者(P<0.05);涂阳或痰培养阳性患者的血清PCT、CRP和sPD-L1分别为(0.43±0.14)ng/ml、(5.43±1.02)mg/L和(6.01±1.01)ng/ml,明显高于涂阴或痰培养阴性者(P<0.05);血清PCT、CRP和sPD-L1诊断涂阳或痰培养阳性的ROC曲线下面积分别为0.683、0.802和0.754。结论肺结核患者血清PCT、CRP、sPD-1水平升高,但仍低于CAP患者,在诊断涂阳或痰培养阳性方面可能有一定应用价值。
Objective To investigate the level of procalcitonin(PCT),C-reactive protein(CRP) and soluble programmed death ligand-1(s PD-L1) in pulmonary tuberculosis patients. Methods From January 2015 to January2017,a total of 132 pulmonary tuberculosis cases in Nanjing Chest Hospital were selected as the subjects,among them,54 were smear positive or sputum culture positive and 78 were negative in smear or sputum culture. There were 110 patients with community acquired pneumonia(CAP) and 100 healthy people were selected as control groups. The serum PCT,CRP and sPD-L1 were detected. Results The PCT,CRP and sPD-L1 in pulmonary tuberculosis cases were(0.38±0.12)ng/ml,(4.80±1.12)mg/L and(5.44±1.03)ng/ml,which was significantly higher than those in healthy people(P<0.05),but lower than those in patients with CAP(P<0.05). The PCT,CRP and sPD-L1 of smear or sputum culture positive patients was(0.43±0.14)ng/ml,(5.43±1.02)mg/L and(6.01±1.01)ng/ml,which was higher than those of smear or sputum culture negative patients(P<0.05). The area under ROC curve of PCT,CRP and sPD-L1 for smear or sputum culture positive diagnosis was 0.683,0.802 and 0.754,respectively. Conclusion The level of PCT,CRP and sPD-1 increased in pulmonary tuberculosis patients,but still lower than those of patients with CAP. It was may be useful in the diagnosis of smear or sputum culture positive pulmonary tuberculosis case.
作者
吴志嵩
马南兰
张亚平
陈杰
茅惠娟
WU Zhi-song;MA Nan-lan;ZHANG Ya-ping;CHEN Jie;MAO Hui-juan(The Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210000,China)
出处
《中国国境卫生检疫杂志》
CAS
2019年第5期352-354,共3页
Chinese Journal of Frontier Health and Quarantine
关键词
肺结核
降钙素原
C反应蛋白
可溶性程序性死亡配体1
痰培养
Pulmonary tuberculosis
Procalcitonin
C-reactive protein
Soluble programmed death ligand 1
Sputum culture
