摘要
目的:观察莫西沙星对耐多药肺结核患者血清降钙素原(PCT)和C反应蛋白(CRP)水平的影响。方法:将76例耐多药肺结核患者按照随机数字表法分为观察组与对照组各38例,观察组在常规化疗的基础上加用莫西沙星,对照组在常规化疗的基础上加用左氧氟沙星。观察2组患者治疗第3、6、12个月的痰菌转阴率;治疗第12个月观察患者肺部X线检查的变化情况;测定2组患者治疗前、治疗第3、6、12个月血清PCT和CRP水平。结果:观察组患者治疗第3、6、12个月的痰菌转阴率均明显高于对照组,差异有统计学意义(P均<0.05);治疗第12个月,观察组患者病灶吸收率、空洞改善率明显高于对照组,差异有统计学意义(P均<0.05);观察组患者治疗第3、6、12个月的血清PCT、CRP水平均明显低于对照组,差异有统计学意义(P均<0.05)。结论:莫西沙星可以明显减少耐多药肺结核患者血清PCT和CRP的表达。
OBJECTIVE：To study the effect of moxifloxacin on Procalcitonin （ PCT） and C-reactive protein（ CRP） levels in patients with multi-drug resistant pulmonary tuberculosis.METHODS：76 patients with multi-drug resistant pulmonary tuberculosispatients were randomly assigned to either observation group or control group of 38 cases each. The observation group received conventional chemotherapy plus moxifloxacin while the control group received conventional chemotherapy plus levofloxacin.The sputum negative-conversion rates at 3, 6 and 12 months, and the X-ray film of the lungs at 12 months and serum levels of PCT and CRP at 3, 6 and 12 months in the two groups were recorded.RESULTS： The sputum negative-conversion rates at 3, 6 and 12 months in the observation group were signficantly higher than in the control group （ P 〈0.05 ）; at 12 months, the focal absorption rate and cavity improvement rate in the observation group were significantly higher than in the control group （ all P〈0.05 ）; serum levels of PCT and CRP at 3 , 6 and 12 months in the observation group were significantly higher than in the control group （ all P〈0.05 ） .CONCLUSIONS：Moxifloxacin use is significantly associated with the declined expression levels of PCT and C-CRP in patients with multi-drug resistant pulmonary tuberculosis.
出处
《中国医院用药评价与分析》
2015年第5期666-667,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
肺结核
莫西沙星
降钙素原
C反应蛋白
Pulmonary tuberculosis
Moxifloxacin
Procalcitonin
C-reactive protein
