期刊文献+

在肺结核病人治疗中加用莫西沙星与缩短痰培养阴转的时间相关 被引量:1

Adding moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis
下载PDF
导出
摘要 目的:探讨标准抗结核治疗方案加用莫西沙星是否能缩短肺结核病人痰培养阴转的时间。方法:成年肺结核病人根据他们的选择被分成2个治疗组:标准方案(HRZE组)和标准方案在治疗的最初2个月加莫西沙星400 mg 1次/d(莫西沙星组)。在治疗开始的前8周,每周收集痰标本3次。通过计算倾向评分来估计进入莫西沙星组的条件概率。影响培养阴转时间的因素通过倾向评分分层采用Cox比例风险回归分析进行研究。结果:62例病人入选莫西沙星组,88例入选HRZE组,分别有51例和72例完成此项研究。2组分别有6例(12%)和12例(16%;P=0.47)在痰培养阴转前因不良反应更改治疗方案。莫西沙星组痰培养阴转时间缩短(HR 2.1,95%可信区间1.4~3.2)。治疗6周后的痰培养阴转率为82%和61%(P=0.011,<0.05/4,采用改良Bonferroni方法计算)。结论:标准抗结核方案在最初的2个月加用莫西沙星与缩短痰培养阴转时间、提高治疗6周的痰培养阴转率及降低肺结核的传播相关。
出处 《国际结核病与肺部疾病杂志》 2010年第1期23-29,共7页 The International Journal of Tuberculosis and Lung Disease
基金 supported by the Institute for Biotechnology and Medicine Industry.
  • 引文网络
  • 相关文献

参考文献31

  • 1Bozeman L,Burman W,Metchock B,Welch L,Weiner M.Fluoroquinolone susceptibility among Mycobacterium tuberculosis isolates from the United States and Canada. Clinical Infectious Diseases . 2005 被引量:1
  • 2Johnson JL,Hadad DJ,Boom WHet al.Early and extended early bactericidal activity of levofloxacin,gatifloxacin and moxifloxacin in pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease . 2006 被引量:1
  • 3Rustomjee R,Lienhardt C,Kanyok Tet al.A PhaseⅡstudy of the sterilising activities of ofloxacin,gatifloxacin and moxifloxacin in pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease . 2008 被引量:1
  • 4Pfyffer GE,Brown-Elliott BA,Wallace RJJ.Mycobacterium. Manual of clinical microbiology . 2005 被引量:1
  • 5Connolly LE,Edelstein PH,Ramakrishnan L.Why is longterm therapy required to cure tuberculosis?. PLoS Med . 2007 被引量:1
  • 6Wang JY,Hsueh PR,Jan ISet al.The effect of smoking on tuberculosis:different patterns and poorer outcomes. International Journal of Tuberculosis and Lung Disease . 2007 被引量:1
  • 7Quantrill SJ,Woodhead MA,Bell CE,Hardy CC,Hutchison AJ,Gokal R.Side-effects of antituberculosis drug treatment in patients with chronic renal failure. European Respiratory Journal . 2002 被引量:1
  • 8Lienhardt C,Manneh K,Bouchier V,Lahai G,Milligan PJ,McAdam KP.Factors determining the outcome of treatment of adult smear-positive tuberculosis cases in The Gambia. International Journal of Tuberculosis and Lung Disease . 1998 被引量:1
  • 9Steele MA,Burk RF,DesPrez RM.Toxic hepatitis with isoniazid and rifampin-a meta-analysis. Chest . 1991 被引量:1
  • 10A.T. Abal B. Jayakrishnan S. Parwer A. El Shamy E. Abahussain and P.N. Sharma.Effect of cigarette smoking on sputum smear conversion in adults with active pulmonary tuberculosis. Respiratory Medicine . 2005 被引量:1

同被引文献13

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部